Balloon catheter

A catheter and balloon technology, applied in the direction of catheters, balloon catheters, drug combinations, etc., can solve the problems of exclusion, balloon size and shape defects, aqueous environment, difficulty in excretory peristalsis, etc.
CN112236188APending Publication Date: 2021-01-15LIPAC ONCOLOGY LLC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
LIPAC ONCOLOGY LLC
Publication Date
2021-01-15

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Abstract

The invention locally delivers a chemotherapeutic or a radiographic contrast agent to an upper tract urothelial carcinoma (UTUC). The invention includes a balloon catheter with a working channel and aballoon placed into the ureter / renal pelvis via retrograde or antegrade ureteral access. The balloon is inflated to temporarily obstruct the ureter, and a formulation with a chemotherapeutic agent isinfused into the working channel of the catheter and allowed to dwell in the ureter / renal pelvis for a time sufficient to allow the formulation to adhere to and penetrate the urothelial wall. The formulations can be liposomal or non-liposomal formulations. At least a portion of the infused chemotherapeutic-agent formulation adheres to the urothelial wall while it is instilled and dwells in the ureter / renal pelvis. The methods of the invention can be performed as an adjuvant therapy to other methods of treating UTUC, including ureteroscopic ablation or resection of the tumor.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of U.S. Provisional Application No. 62 / 666,848, filed May 4, 2018, and U.S. Provisional Application No. 62 / 680,172, filed June 4, 2018. The entire contents of U.S. Provisional Application No. 62 / 666,848, filed May 4, 2018, and U.S. Provisional Application No. 62 / 680,172, filed June 4, 2018 are incorporated by reference into this application. technical field

[0003] The present invention relates to devices and methods for the local delivery of chemotherapeutic agents to upper tracturothelial carcinoma (UTUC). The present invention includes catheters for effecting local delivery of liposomes and other therapeutic formulations into the ureter and / or renal pelvis via retrograde or antegrade catheter access. Background technique

[0004] The urothelium is the layer of tissue that lines the bladder and upper urinary tract. The urothelium expands and contracts to push urine through the u...

Claims

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