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Balloon catheter

A catheter and balloon technology, applied in the direction of catheters, balloon catheters, drug combinations, etc., can solve the problems of exclusion, balloon size and shape defects, aqueous environment, difficulty in excretory peristalsis, etc.

Pending Publication Date: 2021-01-15
LIPAC ONCOLOGY LLC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Intraluminal delivery to the upper urinary tract presents unique challenges given the aqueous environment of ureteral contents, excretory peristalsis, and difficulty penetrating the urothelial barrier
[0011] Existing balloon catheters do not provide optimal drug delivery capabilities, are deficient in balloon size and shape, and do not include effective means to check and regulate pressure in the ureter and / or renal pelvis for safe intraluminal delivery chemotherapeutic agent

Method used

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  • Balloon catheter
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Examples

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Embodiment Construction

[0028] The present invention relates to systems and methods for administering drugs to target sites in body lumens. One embodiment of the invention relates to systems and methods for the local delivery of chemotherapeutic agents to upper tract urothelial carcinoma (UTUC). Figure 1A An exemplary catheter 101 of the present invention is shown having a tubular body with a lumen therethrough. Catheter 101 includes a hollow balloon inflation lumen 160 and a hollow guidewire / drain / drip lumen 170 extending from a proximal end 111 of catheter 101, respectively comprising the proximal end 161 and the proximal end of the balloon inflation lumen. The proximal end 171 of the guidewire / drain / drip lumen. Proximal end 161 of balloon inflation lumen may serve as a balloon infusion port in fluid communication with balloon inflation lumen 160 .

[0029] Balloon inflation lumen 160 and guidewire / drain / drip (GDI) lumen 170 are joined in Y-shaped body luer 165 to form two separate channels (lume...

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Abstract

The invention locally delivers a chemotherapeutic or a radiographic contrast agent to an upper tract urothelial carcinoma (UTUC). The invention includes a balloon catheter with a working channel and aballoon placed into the ureter / renal pelvis via retrograde or antegrade ureteral access. The balloon is inflated to temporarily obstruct the ureter, and a formulation with a chemotherapeutic agent isinfused into the working channel of the catheter and allowed to dwell in the ureter / renal pelvis for a time sufficient to allow the formulation to adhere to and penetrate the urothelial wall. The formulations can be liposomal or non-liposomal formulations. At least a portion of the infused chemotherapeutic-agent formulation adheres to the urothelial wall while it is instilled and dwells in the ureter / renal pelvis. The methods of the invention can be performed as an adjuvant therapy to other methods of treating UTUC, including ureteroscopic ablation or resection of the tumor.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 666,848, filed May 4, 2018, and U.S. Provisional Application No. 62 / 680,172, filed June 4, 2018. The entire contents of U.S. Provisional Application No. 62 / 666,848, filed May 4, 2018, and U.S. Provisional Application No. 62 / 680,172, filed June 4, 2018 are incorporated by reference into this application. technical field [0003] The present invention relates to devices and methods for the local delivery of chemotherapeutic agents to upper tracturothelial carcinoma (UTUC). The present invention includes catheters for effecting local delivery of liposomes and other therapeutic formulations into the ureter and / or renal pelvis via retrograde or antegrade catheter access. Background technique [0004] The urothelium is the layer of tissue that lines the bladder and upper urinary tract. The urothelium expands and contracts to push urine through the u...

Claims

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Application Information

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IPC IPC(8): A61M27/00A61M29/00A61M31/00
CPCA61M25/10A61M31/00A61M31/005A61M25/0097A61M2025/1052A61M25/10186A61M25/0026A61M25/0075A61M25/0084A61M25/0017A61M27/00A61K31/513A61K31/407A61K31/7068A61K31/337A61P35/00A61K9/127A61M2025/0078A61K47/24A61M2025/1056
Inventor M·G·厄夫来因
Owner LIPAC ONCOLOGY LLC
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