Codonopsis sustained-release microcapsule preparation and preparation method thereof

A technology of Codonopside and sustained-release, which is applied in the field of Codonopside sustained-release microcapsule preparation and its preparation, can solve the problem of not finding a patent for sustained-release preparation, achieve stable and suitable blood drug concentration, improve adaptability, and facilitate the The effect of taking

Active Publication Date: 2022-05-17
SHANGHAI NUOCHENG PHARMA
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, no patents on sustained-release preparations related to Codonopsis glycosides have been found

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Codonopsis sustained-release microcapsule preparation and preparation method thereof
  • Codonopsis sustained-release microcapsule preparation and preparation method thereof
  • Codonopsis sustained-release microcapsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0052] The embodiment of the present invention relates to a slow-release microcapsule preparation and a preparation method of a tangshenoside compound, in terms of weight percentage, comprising:

[0053] Codonopsis: 10%-40%;

[0054] Capsule material: 60%-90%;

[0055] The ratio of the capsule material to the styoside is 4:1-6:1;

[0056] The capsule material is a positively and / or negatively charged carrier material;

[0057] The capsule material also includes curing cross-linking agent, wetting agent, pH regulator and deionized water.

[0058] The capsule material is gelatin or one or more combinations of gum arabic, peach gum, psyllium seed gum, cellulose acetate phthalate, sodium carboxymethyl cellulose and alginate.

[0059] Among them, gelatin is a positively charged capsule material.

[0060] Among them, gum arabic, peach gum, psyllium seed gum, cellulose acetate phthalate, sodium carboxymethyl cellulose, and alginate are negatively charged capsule materials.

[00...

Embodiment 1

[0078]

[0079] Add gelatin to 1% calcium chloride solution, add hydrochloric acid solution dropwise to adjust the pH value to 6.1, and obtain the first capsule material solution; prepare sodium alginate into a 3 mg / ml solution, add tangshenoside, stir and mix, And keep the solution temperature at 50° C. to obtain the second capsule material solution. Place the first capsule material solution on a magnetic stirrer, set the stirring speed at 300rpm under the condition of 50°C, slowly add the above-mentioned second capsule material solution into capsule material solution 1, stir for 30 minutes, cool down, and let it stand After settling, the supernatant was decanted, washed with water, filtered, and the obtained microcapsules were vacuum-dried at 50°C. bottling. The yield of tangshenoside sustained-release microcapsules was 90.8%, the encapsulation rate was 74.3%, the drug loading was 21.7%, the cumulative release rate in 4 hours was 45.5%, and the cumulative release rate in...

Embodiment 2

[0081]

[0082] Dissolve gelatin in a water bath at 50°C to prepare a 30 mg / ml solution to obtain capsule material solution 1; weigh tangshenoside and gum arabic, slowly add a small amount of water at 50°C, grind evenly, transfer to a beaker, add water To a sufficient amount of 835ml, put it on a magnetic stirrer, set the stirring speed to 500rpm, and the temperature to 50°C; slowly add the gelatin solution, and stir for 30 minutes. Acetic acid solution was added dropwise to adjust the pH value to 3.8, and stirring was continued for 20 minutes. After forming capsules, add water to dilute 2 times, and then rapidly cool down to below 10°C in an ice bath. Add formaldehyde solution, adjust the pH value to 8.6 with 20% sodium carbonate solution, stir for 10 minutes, let it settle, pour off the supernatant, filter, wash with water, and the obtained microcapsules are vacuum-dried at 50°C. bottling. The yield of tangshenoside sustained-release microcapsules was 89.4%, the encapsu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of preparation of compounds, in particular to a tangshenoside sustained-release microcapsule and a preparation method, comprising the following components: tangshenoside and a capsule material. Wetting agents, curing cross-linking agents and pH regulators are also used in the encapsulation process. At the same time, it also discloses the preparation process of the codonopsis sustained-release microcapsules: dissolving the capsule material in water to obtain a capsule material solution, wetting it with a wetting agent, using a pH regulator to adjust the pH to 3.5-4.5, and the temperature of the solution is 35°C- 70°C. The composition ratio of the tangshenoside slow-release microcapsules provided by the present invention is better, the slow-release effect of the prepared slow-release microcapsules is good, the dispersion performance in water is good, the stability of the drug is improved, and the patient's compliance is enhanced , for the treatment of acute injuries of the gastric mucosa.

Description

technical field [0001] The embodiment of the present invention relates to a herbal drug extract, more specifically to a tangshenoside sustained-release microcapsule preparation and a preparation method thereof. Background technique [0002] Codonopsis pilosula has the functions of invigorating the spleen and lungs, nourishing blood and promoting body fluid. It is used for deficiency of spleen and lung qi, fatigue due to lack of food, cough and shortness of breath, deficiency of qi and blood, pale complexion, palpitation, shortness of breath, thirsty body fluid wound, internal heat and quenching thirst. Studies have shown that Codonopsis decoction has effects on the central nervous system, blood and hematopoietic system, digestive system, endocrine system and immune system. Modern research shows that Codonopsis decoction can prevent coronary heart disease, treat hyperlipidemia, treat hypotension, treat hematopoietic dysfunction caused by chemotherapy, treat dysfunctional ute...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7032A61K9/62A61K9/26A61P1/04A61P9/12A61P13/08A61P25/20A61P29/00A61P31/04A61P35/00A61K47/36A61K47/38
CPCA61K31/7032A61P35/00A61P31/04A61P29/00A61P25/20A61P9/12A61P13/08A61P1/04A61K9/5084A61K9/2081A61K9/5042A61K9/5036A61K9/5047Y02A50/30
Inventor 胡炜
Owner SHANGHAI NUOCHENG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products