Src inhibitor compounds for skeletal muscle modulation, methods and uses thereof
A technology of compounds and compositions, applied in the field of novel SRC inhibitor compounds, capable of solving problems such as low regeneration potential of myoblasts
Inactive Publication Date: 2021-03-26
SOC DES PROD NESTLE SA
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- Abstract
- Description
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- Application Information
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Problems solved by technology
[0006] Previous experimental therapies that have included myoblast transplantation have not been entirely successful because the more committed and differentiated myoblasts have a lower regenerative potential compared to muscle stem cells
Method used
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Embodiment 1
[0233] Example 1: Selection of compounds that modulate muscle stem cells
[0234] Selection of human skeletal muscle myoblasts
[0235] The inventors developed a high content screen to test compounds on primary human adult muscle cells in vitro. Human skeletal muscle myoblasts (HSMM) were purchased from Lonza (https: / / bioscience.lonza.com). These cells were isolated from normal donor upper arm or leg muscle tissue and used after a second passage. Several donors were tested to ensure cell viability and purity before selecting the final donors who were a 36-year-old Caucasian female (Donor 8) and a 20-year-old Caucasian female (Donor 4).
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The present invention relates to novel SRC inhibitor compounds for improving skeletal muscle regeneration to maintain or increase muscle function and / or muscle mass by modulating muscle stem cells. For example, the present invention is useful for subjects to promote muscle repair and / or subjects suffering from precachexia, cachexia, sarcopenia, myopathy, dystrophy and / or recovery after muscle injury or surgery.
Description
technical field [0001] The present invention relates to novel SRC inhibitor compounds for use in improving skeletal muscle regeneration by modulating muscle stem cells to maintain or increase muscle function and / or muscle mass. For example, the present invention may be used in individuals who want to promote muscle repair and / or in individuals suffering from precachexia, cachexia, sarcopenia, myopathy, malnutrition, and / or recovery after muscle injury or surgery. Background technique [0002] Skeletal muscle regeneration is an important mechanism for repairing and maintaining muscle mass and function throughout the lifespan. Skeletal muscle regeneration primarily requires the involvement of myogenic progenitor cells, called muscle stem cells or satellite cells. [0003] Nonproliferative quiescent satellite cells adjacent to resting skeletal muscle can be identified by their variable location between the sarcolemma and basal lamina, high nuclear to cytoplasmic volume ratio, ...
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IPC IPC(8): A61K31/519A61P21/00A61P35/00A61K45/00A01K67/00A23K20/174A23K20/116A23K20/158A23K50/10A23K50/20A23K50/30A23K50/40
CPCA23K20/116A23K20/158A23K20/174A23K50/10A23K50/20A23K50/30A23K50/40A61K31/519A61K45/00A61P21/00A61P35/00A61K2300/00C07D487/04
Inventor D·M·巴伦J·费奇S·卡拉兹J·米肖Y·拉蒂诺P·斯图尔萨茨
Owner SOC DES PROD NESTLE SA
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