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System for predicting one-year joint damage progress of rheumatoid arthritis patient

An arthritis and rheumatoid technology, applied in the medical field, can solve the problems of screening RA patients and unclear specific risks

Active Publication Date: 2021-04-02
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in general, although the clinical characteristics, genetics, serology, and imaging indicators that have been discovered so far can predict the risk of joint destruction progression in RA patients to a certain extent, the specific risks brought by these factors are not clear, and in In actual clinical practice, the same patient may have different risk factors at the same time, so how to calculate the overall effect of these risk factors has not been reported in the literature, so it is difficult for clinicians to accurately screen out RA with a high risk of joint destruction progression based on these risk factors patient

Method used

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  • System for predicting one-year joint damage progress of rheumatoid arthritis patient
  • System for predicting one-year joint damage progress of rheumatoid arthritis patient
  • System for predicting one-year joint damage progress of rheumatoid arthritis patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Construction of the optimized synovial cellular immunology score (see figure 2 ), specifically include the following steps:

[0026] 1. Immunohistochemical staining: The synovial tissue obtained from joint synovial biopsy was fixed, dehydrated and embedded, and serially sectioned for immunohistochemical staining. The main steps include:

[0027] (1) Dewaxing and hydration:

[0028] a. Bake the slices at 60°C for 2 hours;

[0029] b. Add xylene in sequence for 20 minutes × 2 times;

[0030] c. Add 100%, 95%, 85%, and 75% ethanol in turn for 5 minutes;

[0031] d. Wash once with distilled water for 1 minute;

[0032] e. Wash once with PBS for 15 minutes.

[0033] (2) High pressure repair:

[0034] Put in EDTA with a pH of 8.0, boil and put in the slice (the solution has not passed through the tissue), close the lid and start to spray air for 2 minutes and 30 seconds, then quickly reduce the pressure, and naturally cool to room temperature.

[0035] (3) Blocking an...

Embodiment 2

[0069] A system for predicting the one-year progression of joint destruction in patients with rheumatoid arthritis (see image 3 ), the system includes an immunopathology marker score determination module, an optimized synovial cell immunology score calculation module, a joint destruction progression risk comparison module and a risk result display module; the immunopathology marker score determination module is used for Determine immunopathology marker scores for CD90, CD3, CD15, CD20, SL-CD68, CD31, L-CD68, and CD55 and transfer the immunopathology marker scores for 8 markers to the optimized synovium-based cellular immunology score calculation Module, the optimized synovial cell immunology score calculation module according to the calculation formula of O-CISS1, O-CISS1=CD90, CD3, CD20, SL-CD68, CD31, L-CD68 and CD55 immunopathology marker score plus And, the cellular immunological score of O-CISS1 is calculated, and the optimized synovial cellular immunological score calcu...

Embodiment 3

[0073] A system for predicting the progression of joint destruction in patients with rheumatoid arthritis in one year, the system includes an immunopathological marker score determination module, an optimized synovial cell immunology score calculation module, a risk comparison module for joint destruction progression, and a risk result Display module; the immunopathology marker score determination module is used to measure the immunopathology marker scores of CD90, CD3, CD15, CD20, SL-CD68, CD31, L-CD68 and CD55, and the immunopathology marker scores of 8 markers The marker score is transmitted to the optimized synovial cell immunology score calculation module, and the optimized synovial cell immunology score calculation module follows the calculation formula of O-CISS2, O-CISS2=CD90, CD3, CD20, SL-CD68, CD31 The sum of the immunopathological marker scores of CD15 and CD55 is used to calculate the cellular immunological score of O-CISS2, and the optimized synovial cellular immu...

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Abstract

The invention discloses a system for predicting one-year joint damage progress of a rheumatoid arthritis patient. The system comprises an immunopathology marker score determination module, an optimized synovial membrane cellular immunology score calculation module, a joint damage progress risk comparison module and a risk result display module. According to the system, the cell immunological scoreof the synovial membrane with the optimized evaluation index constructed by immunopathology markers related to the synovial membrane is used as the prediction index for the first time to predict thecondition of one-year joint damage progress of rheumatoid arthritis patients, and high-risk patients with the joint damage progress can be accurately screened out one year in advance; high-risk patients can be subjected to intensive treatment one year ahead of time, so that the joint damage progress of the patients can be effectively reduced or blocked, and the method has important significance and clinical value for accurate treatment of RA and reduction of disability rate.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a system for predicting the progression of joint damage in patients with rheumatoid arthritis in one year. Background technique [0002] Rheumatoid arthritis (RA) is a common chronic autoimmune disease characterized by progressive joint destruction, and it is one of the main causes of labor loss and disability in the population. In my country, the total number of patients with RA reaches 5 to 6 million, and it is the primary cause of physical disability in women (accounting for 9.4%, according to the results of the second national sample survey of disabled persons). More than 70% of RA patients have joint erosion and destruction, and with the prolongation of the disease course, the incidence of disability and functional limitation increases. The annual direct cost of RA treatment and the indirect economic loss caused by the disability of the patient's working ability are huge. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16H50/20
CPCG16H50/30G16H50/20
Inventor 戴冽马剑达张学培莫颖倩
Owner SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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