The invention relates to a plaster for treating hyperosteogeny, rheumatism, rheumatoid arthritis and arthritis, which is mainly prepared from the following active pharmaceutical ingredients: long-noded pit viper, cassia twig, raw szechuan aconite, heracleum hemsleyanum michaux, eucommia, radix clematidis, spatholobus stem, club moss, american lopseed, semen momordicae, raw nux vomica, Ningpo yam rhizome, radix sileris, eucommia and the like. The plaster has the advantages of scientific formula and obvious curative effect. Under the synergistic actions of the traditional Chinese medicines, the plaster can perform the functions of expelling wind and clearing away cold, activating blood circulation to dissipate blood stasis, promoting the subsidence of swelling, alleviating pain, nourishing the bone and relaxing tendons, and can promote tissue regeneration, strengthen the body and smooth the meridians, so that the hyperosteogeny is gradually softened, atrophied and healed. Therefore, the plaster has good curative effect on hyperosteogeny, rheumatism, rheumatoid arthritis and arthritis. Clinical application for more than 8 years proves that the plaster has treated 23897 patients with cervical vertebra hyperplasia, knee joint hyperplasia, rheumatism, rheumatoid arthritis, traumatic injury, sprains, lumbar sprain, acute chest pain, stiff neck, strains and lumbar muscle strain, wherein 22056 patients are cured; and thus, the total cure rate is 92.4%.