Fusion protein of anti-C3d targeted single-chain antibody and CD59, and application of fusion protein

A fusion protein and single-chain antibody technology, applied in the field of fusion proteins, can solve problems affecting the targeting effect of anti-C3d antibodies, increase protein molecular weight, etc., and achieve excellent anti-adhesion/anti-inflammatory targeting inhibition effect, vasculitis improvement, high The effect of suppressing efficiency
CN110922489AActive Publication Date: 2020-03-27BEIJING COMPLEMENT THERAPEUTICS LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING COMPLEMENT THERAPEUTICS LTD
Publication Date
2020-03-27

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Abstract

The invention discloses a fusion protein of a single-chain antibody of a human anti-complement C3d molecule and a complement inhibitor CD59. The antibody has excellent antigen binding activity. Biological distribution experiments prove that the fusion protein provided by the invention can be rapidly and highly aggregated at an arthritis part after entering a rheumatoid arthritis mouse model, and has an excellent anti-adhesion / anti-inflammation targeting inhibition effect. In treatment of MRL / lpr lupus erythematosus mice, the fusion protein provided by the invention can obviously improve the survival rate of the mice, and symptoms of proteinuria, glomerular score, interstitial inflammation, vasculitis, crescent / necrosis and the like of a treatment group are obviously improved, so that the fusion protein provided by the invention has an excellent application prospect in preparation of medicaments for treating autoimmune diseases.
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Description

technical field

[0001] The invention provides a fusion protein and belongs to the technical field of polypeptides. Background technique

[0002] The complement system is composed of more than 30 kinds of soluble protein molecules and is a part of the natural immune system. Its components include more than 30 kinds of molecules such as complement intrinsic components, various regulatory factors and complement receptors. The complement system can be activated through three relatively independent and interrelated pathways, thereby exerting various biological effects such as opsonizing phagocytosis, lysing cells, mediating inflammation, immune regulation, and clearing immune complexes, including enhancing phagocytosis, enhancing phagocytosis Chemotaxis of cells; increase of vascular permeability; neutralization of viruses; cell lysis; regulation of immune response, etc. Cell or tissue destruction can also be caused indirectly by complement activation and its deposition on targe...

Claims

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