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Chinese medicinal extract for treating urarthritis, as well as preparation method and application thereof

A gouty arthritis, extract technology, applied in the field of traditional Chinese medicine extract for treating gouty arthritis and its preparation field, can solve problems such as no reports, achieve significant prevention and treatment effect, no toxic and side effects, improve application efficacy and safety sexual effect

Inactive Publication Date: 2012-01-04
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the medicine of preventing and treating gouty arthritis with the extract of red fennel root and quercetin

Method used

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  • Chinese medicinal extract for treating urarthritis, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of Chinese medicine extract (1)

[0036]Wash the red fennel root bark, soak it for 6-24 hours, put it into the extraction container and decoct it for 3-5 times, and the decoction time is 0.5-3 hours each time. The medicinal liquid extracted several times is combined and concentrated into an extract. After the extract is left to stand, ethanol is added for alcohol precipitation, and the ethanol is recovered for precipitation. Take the supernatant after alcohol precipitation, concentrate, pass through a macroporous resin (AB-8) column, collect 30-70% parts, concentrate and dry under reduced pressure to obtain the extract TIL.

[0037] The content of total flavonoids was determined by spectrophotometry. With quercetin as the reference substance and aluminum trichloride as the chromogen, the detection wavelength is 431nm, and the total flavonoid content is 20-80%. Determination by HPLC method, Agilent C 18 Column; mobile phase is acetonitrile-0.1...

Embodiment 2

[0038] Example 2 Preparation of Chinese medicine extract (two)

[0039] Wash red fennel roots or red fennel stems and leaves, soak for 6-24 hours, put them in an extraction container and boil them for 3-5 times, each time for 0.5-3 hours. The medicinal liquid extracted several times is combined and concentrated into an extract. After the extract is left to stand, ethanol is added for alcohol precipitation, and the ethanol is recovered for precipitation. Take the supernatant after alcohol precipitation, concentrate, pass through a macroporous resin (D-101) column, collect 30-70% parts, concentrate and dry under reduced pressure to obtain the extract TIL.

Embodiment 3

[0040] Example 3 Preparation of Traditional Chinese Medicine Extract (3)

[0041] Wash the red fennel root bark, soak it for 6-24 hours, put it into the extraction container and decoct it for 3-5 times, and the decoction time is 0.5-3 hours each time. The medicinal liquid extracted several times is combined and concentrated into an extract. After the extract was left to stand, methanol was added for alcohol precipitation, and the methanol was recovered for precipitation. Take the supernatant after alcohol precipitation, concentrate, pass through a macroporous resin (ZTC-1) column, collect 30-70% parts, concentrate and dry under reduced pressure to obtain the extract TIL.

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Abstract

The invention relates to a Chinese medicinal extract for treating urarthritis, and the Chinese medicinal extract is characterized by being prepared from the following raw material drugs: Illicium henryi root bark, Illicium henryi root, Illicium henryi stem leaves, anisetree bark, Illicium jiadifengpi or albizia julibrissin, wherein the content of total flavonoid in the extract is between 20 and 80 percent. The invention also provides a preparation method and application of the Chinese medicinal extract, as well as a preparation method and application of quercetin. The invention has the advantages that: pharmacological tests prove that the extract mainly prepared from illicium plant has remarkable prevention and treatment effects on acute urarthritis, does not have toxic or side effect, and can be used for preparing medicaments for preventing and treating urarthritis, and rheumatic or rheumatoid arthritis; new application of the quercetin in urarthritis treatment is discovered; according to the preparation method provided by the invention, toxic components are removed, active components are concentrated and remained, the application curative effect and safety are improved, thereby facilitating the safe application in medical industry and related industries.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a traditional Chinese medicine extract for treating gouty arthritis prepared from plants of the genus Anise and its preparation method and application. Background technique [0002] Gout (Gout) is a group of diseases caused by long-term purine metabolism disorder and increased blood uric acid that cause tissue damage. The clinical features are arthritis, tophi, urinary stones and gouty nephropathy. Among them, Gouty arthritis (GA) is more common. It is a metabolic joint disease caused by crystal deposition in joints due to high blood uric acid concentration caused by purine metabolism disorder. The incidence of gout in my country is on the rise. There is no cure for acute gouty arthritis. The drugs used to regulate uric acid metabolism in clinical practice mainly include allopurinol and probenecid, and the drugs used to treat acute gouty arthritis include colchicine and...

Claims

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Application Information

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IPC IPC(8): A61K36/57A61K31/7048C07H17/07A61P19/06A61P19/02A61P29/00
Inventor 黄宝康王国伟梁婕秦路平季晓
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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