Preparation method of periploca forrestii schltr extract as well as product and application of periploca forrestii schltr extract
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A kind of extract, the technology of Teng Teng, which is applied in the field of preparation of Teng Teng extract, can solve the problem of not clearly verifying the pharmacological activity of rheumatoid arthritis
Inactive Publication Date: 2012-08-15
GUIZHOU NORMAL UNIVERSITY
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Although the application discloses that the polysaccharide extract of Rheumatoid Artemisia can be used to prepare the medicine for treating rheumatoid arthritis, it does not clearly verify the effect of the polysaccharide extract of Rheumatoid Artemisiae on rheumatoid arthritis in the biological activity experiment part of its instructions. pharmacological activity of
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Embodiment 1
[0168] Embodiment 1 of the present invention: the preparation of the extract of Caulis japonica
[0169] Take the medicinal material of Rhododendron sinensis, crush it, pass through a 60-mesh sieve, add 8 times the weight of 80% ethanol, reflux extraction in a water bath at 70°C for 2 times, each time for 2 hours, filter, combine the filtrates, and concentrate to a stream with a relative density of 1.5 For the extract, add 1 times the volume of water (that is, the same volume as the liquid extract), refrigerate and let it stand for 24 hours, take the supernatant, recover ethanol, concentrate, and dry to obtain.
Embodiment 2
[0170] Embodiment 2 of the present invention: the preparation of the extract of Caulis japonica
[0171] Take the medicinal material of Rhododendron sinensis, crush it, pass through a 60-mesh sieve, add 9 times the weight of 75% ethanol, reflux extraction in a water bath at 70°C for 2 times, each time for 1.9h, filter, combine the filtrates, and concentrate to a relative density of 1.4 For the liquid extract, add 1 times the volume of water (that is, the same volume as the liquid extract), refrigerate and let it stand for 36 hours, take the supernatant, recover ethanol, concentrate, and dry to obtain.
Embodiment 3
[0172] Embodiment 3 of the present invention: the preparation of the extract of Caulis japonica
[0173] Take the medicinal material of Teng vine, crush it, pass through a 40-mesh sieve, add 10 times the weight of 70% ethanol, reflux extraction in a 75°C water bath for 3 times, each time for 1h, filter, combine the filtrates, and concentrate to a flow immersion with a relative density of 1.3 paste, add 1 times the volume of water, refrigerate and stand for 48 hours, take the supernatant, recover ethanol, concentrate, and dry to obtain.
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Abstract
The invention discloses a preparation method of a periploca forrestii schltr extract as well as the product and application of the periploca forrestii schltr extract. The preparation method comprises the following steps: adding 60%-80% ethanol the weight of which is 8-12 times that of the medicinal material periploca forrestii schltr into the taken periploca forrestii schltr; carrying out reflux extraction for 1-3 times, wherein each reflux extraction lasts for 1-3 hours; filtering, mixing filtrates and concentrating until the relative density of the mixed filtrate is 1.2-1.5; adding water the volume is the same as that of the mixed filtrate; and refrigerating and standing for 12-48 hours, taking supernate, recovering ethanol and drying so as to obtain the extract. In the method, the ethanol extraction and water precipitation process is adopted to extract the medicinal material periploca forrestii schltr, and the parameters of the ethanol extraction process and the water precipitation process are optimized respectively. The obtained extract mainly contains flavonoid and triterpene compounds. Tests prove that the extract has obvious therapeutical effects on primary and secondary inflammatory reaction of AA rats and has good effects in the aspects of inflammation resistance, detumescence and relief of arthritis injuries of AA rats. Thus, the extract can be applied to the preparation of medicines for rheumatoid arthritis.
Description
technical field [0001] The present invention relates to a preparation method of the extract of Teng japonica and its product and use, which belong to the technical field of traditional Chinese medicine. Background technique [0002] Black bone vine (Periploca forrestii Schltr.) is the rhizome of the genus Periploca forrestii Schltr., which has the effects of dredging the meridian and activating collaterals, dispelling stasis and relieving pain, and expelling wind and dampness. It is widely used in the folk to treat closed soft tissue injuries, rheumatism Ethnic medicine with rheumatoid and other diseases. Black bone vine is the best medicine used by Miao people for thousands of years to treat rheumatism, rheumatoid diseases and neck, shoulder, arm, waist and leg pain. "Three treasures of Miao medicine, black bone vine, ginkgo, and stone grass" are widely spread among the people , because the black bone vine is easy to use and the effect is very obvious, so it has the reputa...
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