Uses of di-indole methyl hydride and its derivant in treating rheumatoid arthritis

A technology for diindolylmethane and rheumatoid arthritis, which is applied in the field of treating rheumatoid arthritis, can solve problems such as difficulty in the treatment of rheumatoid arthritis, meets the requirements of relatively preparation equipment, has high encapsulation rate and is easy to store and transport effects

Active Publication Date: 2009-05-13
宁国市吴越医药科技有限公司
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  • Abstract
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Problems solved by technology

However, studies have shown that systemic administration of IFN-γ cannot completely block the onset of rheumato

Method used

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  • Uses of di-indole methyl hydride and its derivant in treating rheumatoid arthritis
  • Uses of di-indole methyl hydride and its derivant in treating rheumatoid arthritis
  • Uses of di-indole methyl hydride and its derivant in treating rheumatoid arthritis

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Embodiment Construction

[0030] The 3,3'-diindolylmethane of the present invention is applied to the treatment of rheumatoid arthritis and the preparation of physiological saline injection after being dissolved by cyclodextrin. In a specific implementation process, the cyclodextrin used includes α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin.

[0031] 1. DIM uses splenocyte suspension for activity screening

[0032] Different DIM derivatives were dissolved in dimethyl sulfoxide (DMSO) to make 1000× test stock solutions. The ICR mice were killed by neck dislocation, the mouse spleen was taken out under aseptic conditions, the spleen was cut into pieces with ophthalmic scissors, the spleen fragments were crushed in an eight-mesh mesh sieve, washed repeatedly with sterile saline, and the splenocytes were collected and suspended through the mesh sieve. liquid. The crude spleen cell suspension was centrifuged at 1000 rpm for five minutes to obtain crude spleen cell pellet. Resuspend the crude splenoc...

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Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to application of diindolymethane and the derivant thereof in rheumatoid arthritis and preparation of novel aqueous solution preparation of diindolymethane and the derivant thereof. The diindolymethane and the derivant thereof can effectively improve the level of interferon - Gamma in vitro and in vivo and can regulate the immunity of the organism, thereby stopping the happening and development of diseases and reducing the injury caused by the diseases. In addition, the intermediary mainly involved in the water solution preparation of the product is cyclodextrin. The water solution preparation of the product can effectively improve the water solubility, and is convenient for use. The application of the water solution preparation of the product is not limited only within the application on treatment of rheumatoid arthritis, but also includes the application of diindolymethane and the derivant thereof in treatment of other diseases, such as tumor and androgen and estrogen related diseases.

Description

1. Technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of diindolylmethane and its derivatives to treat rheumatoid arthritis. 2. Background technology [0002] Rheumatoid arthritis is one of the most common connective tissue diseases. It is a multiple inflammatory autoimmune disease mainly involving the surrounding joints. It is characterized by symmetrical and peripheral chronic inflammatory lesions of multiple joints. The pathology is Chronic synovitis invades the underlying cartilage and bone, causing joint destruction, loss of labor force, and even disability. The treatment of rheumatoid arthritis in the past mainly focused on non-steroidal anti-inflammatory drugs, glucocorticoids, immunosuppressants and so on. However, traditional treatments have shortcomings such as unclear targets and relatively large side effects. Although the pathogenesis of rheumatoid arthritis is unclear, studies in rec...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61P29/00A61P19/02A61P35/00A61P31/12
Inventor 张峻峰董磊夏苏华陈江宁
Owner 宁国市吴越医药科技有限公司
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