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Preparation and applications of paeonol controlled-release preparation

A sustained-release preparation, the technology of paeonol, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations of non-active ingredients, etc., can solve the problems of short elimination half-life, high frequency of medication, and difficult storage

Inactive Publication Date: 2011-03-23
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are several key problems of paeonol, such as easy volatilization and difficult storage; low solubility, which is not conducive to the dissolution and absorption of paeonol in the human body; short elimination half-life, high frequency of medication, etc. cannot be solved at the same time

Method used

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  • Preparation and applications of paeonol controlled-release preparation
  • Preparation and applications of paeonol controlled-release preparation
  • Preparation and applications of paeonol controlled-release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: Paeonol sustained-release tablet

[0048] [Prescription] Paeonol 60mg

[0049] HPMC K4M 40mg

[0050] HPMC K100M 20mg

[0051] Lactose 84mg

[0052] Magnesium Stearate 1%

[0053] [Preparation process] pass paeonol through 100 mesh sieve and HPMC K4M 、HPMC K100M , lactose and other auxiliary materials are mixed evenly, and an appropriate amount of magnesium stearate is added as a lubricant. After mixing, the whole powder is directly compressed into tablets, and the product is obtained.

[0054] [Dissolution] The method refers to "Chinese Pharmacopoeia" 2005 Edition Part II Dissolution Determination Method (Appendix XC Method 3) and Dissolution Determination Method (Appendix XD Method 1), using 900ml distilled water as the release medium, and the rotation speed is 100r min -1 , temperature 37.0°C. At 2, 4, 6, 8, 10, and 12 hours, 6ml samples were taken respectively and distilled aqueous solution of the...

Embodiment 2

[0055] Embodiment 2 paeonol sustained release tablet

[0056] [Prescription] Paeonol 60mg

[0057] HPMC K4M 40mg

[0058] HPMC K100M 20mg

[0059] Lactose 108mg

[0060] Magnesium Stearate 1%

[0061] [Preparation process] pass paeonol through 100 mesh sieve and HPMC K4M 、HPMC K100M , lactose and other auxiliary materials are mixed evenly, and an appropriate amount of magnesium stearate is added as a lubricant. After mixing, the whole powder is directly compressed into tablets, and the product is obtained.

Embodiment 3

[0062] Embodiment 3: Paeonol sustained release tablet

[0063] [Prescription] Paeonol 60mg

[0064] HPMC K4M 30mg

[0065] HPMC K100M 30mg

[0066] Lactose 84mg

[0067] Magnesium Stearate 1%

[0068] [Preparation process] Paeonol is passed through a 100 mesh sieve and mixed with HPMC K4M 、HPMC K100M , lactose and other auxiliary materials are mixed evenly, and an appropriate amount of magnesium stearate is added as a lubricant. After mixing, the whole powder is directly compressed into tablets, and the product is obtained.

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Abstract

The invention relates to a preparation and applications of a paeonol controlled-release preparation in the technical field of the medicine. The paeonol controlled-release preparation refers to a group of controlled-release and long-time effective preparations which contain the microspheres and gel matrix tablets used for preparing tablets or capsules, and thermosensitive in situ gel for external use, wherein the specifications of the prepared paeonol controlled-release preparation are 60mg and 120mg; under special conditions, the accumulative release rate at 2h is less than 20% of the labeled amount, the accumulative release rate at 6h is 40-60% of the labeled amount and the accumulative release rate at 12h is more than 80% of the labeled amount respectively; and the paeonol controlled-release preparation can be used to cure rheumatoid arthritis. By using the thermosensitive in situ gel for external use, the preparation residence time of the affected part can be significantly prolonged.

Description

technical field [0001] The invention relates to the preparation and application of a paeonol sustained-release preparation, specifically the preparation method and clinical indications of the paeonol sustained-release preparation. Background technique [0002] Rheumatoid Arthritis (RA for short) is an autoimmune disease characterized by chronic inflammatory lesions in joints and periarticular tissues. , mostly symmetrical. The main pathological changes were chronic inflammation of synovial membrane, cell infiltration, pannus formation, erosion of cartilage and bone tissue. According to statistics, the incidence rate of RA in foreign countries is about 1%-2%, and it is as high as 5% in some regions; the incidence rate in various parts of our country is slightly different, with an average of 0.4%. -4.4 million. When the patient's condition is mild, he only feels local joint stiffness and pain, and when it is severe, it will cause joint swelling and damage throughout the bod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/52A61K9/00A61K31/12A61K47/38A61K47/32A61P19/04A61P29/00
Inventor 胡容峰彭代银赵红高宇徐亚静尹辉
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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