Staphylococcus aureus inhibitor, and preparation method and application thereof

A staphylococcus, golden yellow technology, applied in the direction of antibacterial drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of lack of effective treatment methods, endangering the cattle industry, etc., achieve good application prospects, reduce inflammatory symptoms, and restore cell status Effect

Active Publication Date: 2021-04-16
山东中农普宁药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Dairy cow mastitis is an important disease that seriously endangers the cattle industry, especially the mastitis caused by Staphylococcus aureus, and there is still a lack of effective treatment methods

Method used

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  • Staphylococcus aureus inhibitor, and preparation method and application thereof
  • Staphylococcus aureus inhibitor, and preparation method and application thereof
  • Staphylococcus aureus inhibitor, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The staphylococcus aureus inhibitor designed by the patent of the present invention is hydrogen-rich glycerin, and its production method is: use hydrogen production equipment to produce high-purity hydrogen; The injection pressure is 400MPa, and the stable pressure is maintained for 1 hour. During the hydrogen injection process, the stirring device is started to continuously stir the glycerin. The stirring speed is 3000 rpm, so that the hydrogen gas is gradually and evenly dispersed in the glycerol in the form of small bubbles. After 1 hour, stop the booster pump to obtain a hydrogen-rich glycerin oil-gas mixture, in which the amount of hydrogen is not less than 7 mg / L, and the diameter of the small bubbles is not greater than 1 μm.

Embodiment 2

[0023] The staphylococcus aureus inhibitor designed by the patent of the present invention is hydrogen-rich glycerin, and its production method is: use hydrogen production equipment to produce high-purity hydrogen; The injection pressure is 400MPa, and the pressure is kept stable for 1.5 hours. During the hydrogen injection process, the stirring device is started to continuously stir the glycerin. The stirring speed is 3600 rpm, so that the hydrogen gas is gradually and evenly dispersed in the glycerol in the form of small bubbles. After 1.5 hours, stop the pressurizing pump to obtain a hydrogen-rich glycerin oil-gas mixture, the amount of hydrogen is not less than 8mg / L, and the diameter of small bubbles is not greater than 1μm.

Embodiment 3

[0025] The staphylococcus aureus inhibitor designed by the patent of the present invention is hydrogen-rich glycerin, and its production method is: use hydrogen production equipment to produce high-purity hydrogen; The injection pressure is 400MPa, and the pressure is kept stable for 2 hours. During the hydrogen injection process, the stirring device is started to continuously stir the glycerin. The stirring speed is 4200 rpm, so that the hydrogen gas is gradually and evenly dispersed in the glycerol in the form of small bubbles. After 2 hours, stop the booster pump to obtain a hydrogen-rich glycerin oil-gas mixture, the amount of hydrogen is not less than 8.5mg / L, and the diameter of the small bubbles is greater than 1 μm.

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Abstract

The invention relates to a staphylococcus aureus inhibitor, and a preparation method and application thereof, and belongs to the technical field of medical compositions. The staphylococcus aureus inhibitor is hydrogen-rich glycerol, and hydrogen is uniformly dispersed in glycerol in the form of small bubbles. Hydrogen is pressurized by hydrogen-rich glycerol in a stirring state and is dispersed in glycerol in a form of small bubbles. The hydrogen-rich glycerol designed by the invention can effectively inhibit the growth of staphylococcus aureus, can be applied to treatment of staphylococcus aureus mastitis, and has a remarkable effect.

Description

technical field [0001] The invention relates to the technical field of medical compositions, in particular to a staphylococcus aureus inhibitor and its preparation method and application. Background technique [0002] Dairy cow mastitis is an important disease that seriously endangers the cattle industry, especially the mastitis caused by Staphylococcus aureus, and there is still a lack of effective treatment. When infection occurs, pattern recognition receptors in breast tissue are rapidly activated and recognize pathogen-associated molecular patterns (PAMPs) to initiate an inflammatory response. TLR2 and Nod2 signaling pathways play an important role in Staphylococcus aureus infection, and they can rapidly activate multiple inflammation-related signaling pathways, such as NF-KB signaling pathway and MAPK signaling pathway. Myd88 is a key adapter protein in the TLR signaling pathway, RIP2 is the core adapter protein in the Nod2 signaling pathway, and IKB is an important pr...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K33/00A61P15/14A61P31/04A61K31/047
Inventor王金纪耿娜张广斌刘建柱李桂华于宏庚承芳张劲梁潇米雪丽康鲁风
Owner山东中农普宁药业有限公司