Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ultraviolet light-induced inflammation suppressor comprising alternative autophagy inducer

A UV and inhibitor technology, applied in skin care preparations, medical preparations containing active ingredients, testing pharmaceutical preparations, etc., can solve problems such as insufficient insights and achieve the effect of UV damage

Pending Publication Date: 2021-07-23
SHISEIDO CO LTD
View PDF15 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As mentioned above, alternative autophagy is a newly discovered autophagy pathway in recent years, and its influence on physiological mechanisms and involvement in diseases has been studied, but sufficient insights have not yet been obtained

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ultraviolet light-induced inflammation suppressor comprising alternative autophagy inducer
  • Ultraviolet light-induced inflammation suppressor comprising alternative autophagy inducer
  • Ultraviolet light-induced inflammation suppressor comprising alternative autophagy inducer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0085] Effects of autophagy inhibitors and inducers on UV-induced inflammation

[0086] Normal human epidermal keratinocytes (NHEK) (manufactured by Kuraboo) were seeded in a 6-well plate, and cultured in a medium for epidermal keratinocyte expansion (EpiLife-KG2; manufactured by GIBCO) until subconfluent. Thereafter, the culture medium containing 3-methyladenine (3-MA) ​​(manufactured by R&D Corporation; final concentration 1 mM), known as an autophagy inhibitor, and the medium containing Ramen, known as an autophagy inducer, were respectively exchanged. The medium was cultured with pamycin (manufactured by Enzo Life Science; final concentration: 0.5 μM) for 3 hours. After culturing, the medium was discarded, and PBS was added at 20mJ / cm 2 The irradiation intensity is irradiated with ultraviolet rays (290-315nm). After ultraviolet irradiation, culture was continued again under the above medium conditions containing 3-MA or rapamycin, and 48 hours later, respective culture...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention addresses the problem of providing an ultraviolet light-induced inflammation suppressor. The present invention is based on the finding that an alternative autophagy (Atg5 / Atg7-independent autophagy) participates in the suppression of ultraviolet light-induced inflammation. Thus, the above problem is solved by providing an alternative autophagy inducer.

Description

technical field [0001] The present invention relates to an inhibitor of ultraviolet-induced inflammation comprising an agent that induces alternative autophagy as an active ingredient. In addition, the present invention also relates to a method for screening alternative autophagy inducers and ultraviolet-induced inflammation inhibitors using alternative autophagy activity as an index, and a method for evaluating resistance against ultraviolet-induced inflammation in human skin. Background technique [0002] Decomposition and regeneration mechanisms of cytoplasmic components (organelles, cytoplasmic proteins, etc.) in cells exist ubiquitin-proteasome system responsible for selective proteolysis, and autophagy, which is a non-selective system called bulk degradation in principle Mechanisms. Autophagy, also referred to as autophagy, can enclose cytoplasmic components for decomposition by a double membrane (separation membrane), and then fuse with lysosomes after closing the is...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K45/00A61K8/9789A61K8/9794A61K36/185A61K36/28A61K36/38A61K36/53A61K36/65A61K36/738A61K36/82A61K36/899A61P17/16A61P29/00A61P43/00A61Q17/04A61Q19/08C12Q1/06G01N33/15G01N33/50
CPCA61K8/9789A61K8/9794A61K36/185A61K36/28A61K36/38A61K36/53A61K36/738A61K36/65A61K36/82A61K36/899A61K45/00A61P17/16A61P29/00A61P43/00A61Q19/08A61Q17/04G01N33/15G01N33/502G01N2800/40A61K2300/00
Inventor 长谷川达也中岛优哉宫井雅史清水重臣本田真也
Owner SHISEIDO CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com