Application of ginsenoside composition in preparation of medicine for preventing and treating alopecia by acting on hair follicle tissue

A technology of ginsenosides and compositions, applied in the field of medicine, to achieve the effect of simple ingredients

Active Publication Date: 2021-08-03
南京瑞爱丝生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In particular, there has been no report of a pharmaceutical composition containing...

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  • Application of ginsenoside composition in preparation of medicine for preventing and treating alopecia by acting on hair follicle tissue
  • Application of ginsenoside composition in preparation of medicine for preventing and treating alopecia by acting on hair follicle tissue

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Embodiment 1

[0027] Embodiment 1: the effect of preventing and treating alopecia of ginsenoside composition of the present invention

[0028] In order that the ginsenoside composition of the present invention has the effect of preventing hair loss and growing hair, 80 hair loss subjects were selected, aged 18-60, with an average age of 30.5 years, half male and half male. The above-mentioned hair loss subjects were divided into 4 groups, 20 subjects in each group.

[0029] Each group is given the following conventional hair care essence respectively: (1) blank conventional hair care essence matrix: (2) the composition containing ginsenoside Rg1 and ginsenoside Re and the hair care essence of the conventional hair care essence matrix, wherein by weight percentage Ginsenoside Rg1 accounts for 5% of the total weight of the hair care essence, and ginsenoside Re accounts for 4% of the total weight of the hair care essence; Ginsenoside CK accounts for 1% of the total weight of hair care essence...

Embodiment 2

[0034] Example 2: Effects of the ginsenoside composition of the present invention on the growth of mouse hair follicles and the proliferation of hair follicle bulb cells in vitro

[0035] In Vitro Experiment of Mouse Vibrissa Hair Follicles

[0036] 1. Mouse vibrissae hair follicle organ culture

[0037] C57BL / 6J mice aged 4-6 weeks were sacrificed by cervical dislocation, their beards on both sides were cut off, and their vibrissae were disinfected with 75% alcohol three times. Then put them in Williams culture medium, under a dissecting microscope, use micro scissors and tweezers to separate the anagen hair follicles, and cut off the upper 1 / 3 part of the hair follicles. Hair follicle culture was carried out in a 96-well plate, one hair follicle was placed in each well, and 0.2 mL of Williams culture medium serum-free medium was added to each well, which contained transferrin 10 mg / L, penicillin 100 U / mL, streptomycin 100μg / mL and other components, placed in 37 ℃, 5% CO ...

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Abstract

Firstly, the invention provides application of the ginsenoside composition in preparation of a medicine for preventing and treating alopecia by acting on hair follicle tissues. The ginsenoside composition is composed of ginsenoside Rg1, ginsenoside Re and ginsenoside CK, the ginsenoside Rg1 and the ginsenoside Re are main active components, and the ginsenoside CK is an auxiliary component. Secondly, the invention further provides application of the ginsenoside composition in preparation of a medicine for improving hair follicle tissue activity, the medicine is directly smeared or sprayed on scalp to promote hair follicles in a resting period to enter a regeneration period, and hair growth is promoted. Then, the invention further provides application of the ginsenoside composition in preparation of a medicine for improving the activity of the in-vitro cultured hair follicle tissue, the ginsenoside composition is prepared into a tissue culture solution to act on the in-vitro cultured hair follicle tissue, so that the activity of the cultured hair follicle tissue can be improved, and the survival rate of transplanted hair follicles is remarkably improved.

Description

technical field [0001] The present invention belongs to the field of medicine, and relates to a new application of a ginsenoside composition composed of ginsenoside Rg1, ginsenoside Re and ginsenoside CK, and specifically relates to the preparation of the above-mentioned ginsenoside composition in the preparation of a medicine for preventing and treating hair loss by acting on hair follicle tissue the use of. Background technique [0002] In addition to functions such as heat preservation and protection of the scalp from external damage, hair plays an important role in beautifying the personal image. A normal person loses about 40-100 hairs per day on average. The normal shedding hairs are hairs in the catagen and telogen phases. Since the hairs entering the catagen phase and the hairs newly entering the growth phase are constantly in a dynamic balance, the normal amount of hair can be maintained. Pathological alopecia is the abnormal or excessive loss of hair, which has ma...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P17/14
CPCA61K9/0014A61K31/704A61P17/14A61K2300/00
Inventor 季辉王权
Owner 南京瑞爱丝生物科技有限公司
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