Sesquiterpenoids with anti-influenza virus activity and their applications
A technology of influenza virus and influenza A virus, applied in the field of medicine, can solve problems such as failure and destructive power, pandemic of influenza virus, mutation of influenza virus, etc., and achieve good anti-influenza virus activity, good research and application prospects
Active Publication Date: 2022-07-08
SOUTHERN MEDICAL UNIVERSITY
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Problems solved by technology
Due to the mixing of viral genes, influenza viruses are prone to rapid mutations to produce new influenza virus strains, which often lead to the failure of existing clinical drugs and extremely destructive influenza virus pandemics
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[0033] The idea of the present invention and the technical effects produced will be clearly and completely described below with reference to the embodiments, so as to fully understand the purpose, characteristics and effects of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative efforts are all within the scope of The scope of protection of the present invention.
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Abstract
The invention discloses sesquiterpenoids with anti-influenza virus activity and applications. The sesquiterpenoids are shown in formula (1-14). The present invention obtains 14 sesquiterpenoids through separation and screening, and Through the antiviral activity study, it is found that these sesquiterpenoids have good anti-influenza virus activity, and the selectivity index of some compounds against influenza virus is greater than 500, showing a good research prospect.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a sesquiterpenoid compound with anti-influenza virus activity and application thereof. Background technique [0002] Influenza A viruses (IAVs) are a major pathogenic microorganism that can be transmitted among humans, birds, dogs, pigs and other animals, and are the main cause of seasonal epidemics and opportunistic pandemics, often worldwide Caused the death of millions of people and had a serious impact on human health and economic development. Due to the mixing of viral genes, influenza viruses are prone to rapid mutation to produce new influenza virus strains, which often lead to the failure of existing clinical drugs and the destructive influenza virus pandemic. Therefore, it is necessary to develop new anti-influenza virus drugs with different mechanisms of action from existing drugs to prevent and treat influenza virus infection. SUMMARY OF THE INVENTION ...
Claims
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IPC IPC(8): C07C49/733C07C35/36C07C35/37C07D303/14C07D307/92A61P31/16A61K31/047A61K31/122A61K31/336A61K31/343C12P7/26C12P7/18C12P17/02C12P17/04C12R1/465
CPCC07C49/733C07C35/36C07C35/37C07D303/14C07D307/92A61P31/16C12P7/26C12P7/18C12P17/02C12P17/04C07C2602/28C07C2603/78Y02A50/30
Inventor 何坚谢茜陆盛胜胡家楠李芳芳
Owner SOUTHERN MEDICAL UNIVERSITY
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