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Application of aloesome in preparation of medicine for treating ulcerative colitis

A technology of ulcerative colitis and aloe vera pine, applied in the direction of drug combination, antipyretics, anti-inflammatory agents, etc., can solve the problems of less research on pharmacological activity and low content of aloe vera pine, so as to inhibit the process of UC and improve the inflammatory response , the effect of inhibiting pyroptosis

Inactive Publication Date: 2021-11-02
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of aloe pine in aloe is low and there are few studies on related pharmacological activities.

Method used

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  • Application of aloesome in preparation of medicine for treating ulcerative colitis
  • Application of aloesome in preparation of medicine for treating ulcerative colitis
  • Application of aloesome in preparation of medicine for treating ulcerative colitis

Examples

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Embodiment Construction

[0022] In order to better understand the technical content of the present invention, specific examples are provided below to further illustrate the present invention.

[0023] The experimental methods used in the examples of the present invention are conventional methods unless otherwise specified.

[0024] The materials and reagents used in the examples of the present invention can be obtained from commercial sources unless otherwise specified.

[0025] Aloe pine can be obtained by extracting plants of the genus Aloe or rhubarb, or by chemical synthesis.

[0026] Chinese name: Aloe pine, molecular formula C 13 h 12 o 4 ; Molecular weight: 232.23198; English name: aloesone; Other names: 2-acetonyl-7-hydroxy-5-methylchromone (2-acetonyl-7-hydroxy-5-methyl-chromone), 2-acetonyl-7-hydroxy -5-methyl-chromen-4-one(2-acetonyl-7-hydroxy-5-methyl-chromen-4-one), 2-(2-oxopropyl)-7-hydroxy-5-methyl-4H -1-benzopyran-4-one(2-(2-oxopropyl)-7-hydroxy-5-methyl-4H-1-benzopyran-4-one), 7-...

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Abstract

The invention relates to an application of aloesome in preparation of the medicine for treating ulcerative colitis, the treatment effect of the aloesome on ulcerative colitis is researched in vivo and in vitro, and it is found that the aloesome can inhibit the activity of MPO in vitro and inhibit macrophages from generating inflammatory factors such as IL-1beta and IL-18, so that pyroptosis is inhibited; and LTB4 and TNF alpha of DSS model mouse plasma can be reduced in vivo. Therefore, the aloesome can improve inflammatory response of mice with colitis, so that the ulcerative colitis process is effectively inhibited, and the aloesome can be used for preparing the medicine for treating ulcerative colitis.

Description

technical field [0001] The invention relates to the field of medicines for ulcerative colitis, in particular to the use of aloe vera pine in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic autoimmune disease characterized by peptic ulcers. In recent years, its incidence has doubled all over the world. Wait for the torment of illness. IBD mainly includes ulcerative colitis (ulcerative colitis, UC) and Crohn's disease (Crohn's disease, CD), both of which are clinically characterized by alternating periods of activity and remission, and most of them are chronic and recurrent. There are many causes of IBD, mainly including environmental, genetic, infection and immune factors. The incidence of UC in my country is much higher than that of CD. [0003] At present, the commonly used drugs for the treatment of ulcerative colitis in internal medicine mainly include aminosalicylic acid drugs, g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K36/896A61K36/886A61P1/04A61P29/00
CPCA61K31/352A61K36/896A61K36/886A61P1/04A61P29/00
Inventor 李友宾王雪松龚晶雯曾婷婷谭银丰王燕徐俊裕
Owner HAINAN MEDICAL COLLEGE
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