Detection system for severe acute respiratory syndrome coronavirus 2

A technology for respiratory syndrome, coronavirus, applied in the field of systems for identifying pathogenic microorganisms

Pending Publication Date: 2021-12-24
TELEFLEX MEDICAL INC
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  • Abstract
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  • Detection system for severe acute respiratory syndrome coronavirus 2
  • Detection system for severe acute respiratory syndrome coronavirus 2
  • Detection system for severe acute respiratory syndrome coronavirus 2

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Embodiment Construction

[0014] figure 1 A schematic diagram of an exemplary SARS-CoV-2 infection detection system 10 according to aspects of the present invention is shown. The SARS-Co V-2 infection detection system is configured to process a sample and determine whether the sample contains one or more predetermined pathogens. A SARS-CoV-2 infection detection system according to an embodiment of the present invention includes a sampling device 20 , a lysis chamber 30 , a filter 40 , a meter 50 , a nucleic acid sequence-based (NASBA) fluid network 60 and an instrument 70 . The SARS-CoV-2 infection detection system also includes a sample processor 80, such as a cartridge, which includes at least a NASBA fluid network and may include any or all of a lysis chamber, a filter, and a meter. The sample processor is configured to connect to the sampling device and to receive and process samples contained within the sampling device. The sample processor can be disposable and replaceable, and can be adapted t...

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Abstract

The invention relates to a detection system for severe acute respiratory syndrome coronavirus 2. The detection system comprises a sampling device, a cracking chamber, an NASBA fluid network and an analysis instrument. The sampling device is configured to contain a sample containing a pathogen target sequence for SARS-CoV-2. The NASBA fluid network includes an enzyme, a forward primer and a reverse primer for amplifying a predetermined gene sequence in a pathogen target sequence contained within the lysate. The forward primer has an oligonucleotide sequence selected from the following groups: SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, SEQ ID NO: 13 and SEQ ID NO: 17. The reverse primer has oligonucleotide sequences selected from the following groups: SEQ ID NO: 2, SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 14 and SEQ ID NO: 18. The molecular beacon is configured to attach to a pathogen target sequence. The beacon has an oligonucleotide sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 7, SEQ ID NO: 11, SEQ ID NO: 15, and SEQ ID NO: 19 and a fluorophore.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 63 / 017043, filed April 29, 2020, and U.S. Provisional Patent Application No. 63 / 063731, filed August 10, 2020, which was filed on September 4, 2020 Continuation-in-Part of PCT International Patent Application PCT / US20 / 49394 filed, claiming priority to U.S. Provisional Patent Application No. 62 / 897057, filed September 6, 2019, their disclosures Incorporated herein by reference in its entirety. technical field [0003] The present invention generally relates to systems for identifying pathogenic microorganisms. More specifically, the present invention relates, for example, to a system for real-time identification of pathogenic microorganisms and / or their antibiotic resistance in biological samples via nucleic acid sequence-based amplification (NASBA) of specific RNA sequences. Background technique [0004] The novel coronavirus (SARS-CoV-2) tha...

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Application Information

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IPC IPC(8): C12Q1/70C12Q1/6844C12N15/11
CPCC12Q1/701C12Q1/6844C12Q2531/143C12Q2563/107C12Q2527/125C12Q1/70C12Q2600/16B01L2200/0663
Inventor 迈克尔·布查德史蒂文·布吕泽克切尔西·科纳普劳伦·麦克丹尼尔杰西卡·斯莫罗伯特·乌尔里希维多利亚·瓦格纳
Owner TELEFLEX MEDICAL INC
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