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Particulate matter capturing system and method

A particle and component technology, applied in the field of particle capture system, can solve the problems of complex operation, low particle separation efficiency and high cost, and achieve the effect of uniform liquid flow distribution

Pending Publication Date: 2022-03-25
武汉生民医疗科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The purpose of this application is to provide a system and method for capturing particles (such as cancer cells) to solve the problems of low particle separation efficiency, easy clogging, complicated operation, high cost and living particles (such as cancer cells) caused by current membrane filtration. ) The problem of low survival rate

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  • Particulate matter capturing system and method
  • Particulate matter capturing system and method

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Embodiment Construction

[0045] The present invention will be described in detail below in conjunction with specific embodiments and examples, and the advantages and various effects of the present invention will be presented more clearly. Those skilled in the art should understand that these specific implementations and examples are used to illustrate the present invention rather than limit the present invention.

[0046] Throughout the specification, unless otherwise specified, terms used herein should be understood as commonly used in the art. Therefore, unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, this specification shall take precedence.

[0047] Unless otherwise specified, various raw materials, reagents, instruments and equipment used in the present invention can be purchased from the market or prepared by existing methods.

[0048] ...

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Abstract

The invention relates to a particulate matter capturing system and method, and belongs to the technical field of liquid biopsy, the system comprises a centrifugal tube, the centrifugal tube comprises a centrifugal tube body and a membrane separation assembly, the centrifugal tube body is provided with a hanging piece, an inner cavity of the centrifugal tube is provided with an assembly mounting cavity and a centrifugal liquid containing cavity, and the centrifugal liquid containing cavity is arranged at one end away from the hanging piece; the membrane separation assembly is mounted in the assembly mounting cavity; on the basis of existing fluid auxiliary separation, through the design of an assembly device for centrifugal membrane filtration by using a horizontal angle rotor, the problems that particulate matters (such as cells) are different in stress on the inner side and the outer side of a membrane during centrifugation and are easy to accumulate at the edge to cause blockage, and the membrane filtration efficiency and the cell survival are influenced are solved.

Description

technical field [0001] The invention belongs to the field of liquid biopsy, and in particular relates to a particle capture system and method. Background technique [0002] Enrichment of circulating tumor cells (CTCs) exploits differences between tumor cells and other blood constituent cells, including differential expression of cell surface proteins or unique physical properties of cells. Mainly include: biological-based immune capture and large separation based on physical methods (such as: membrane filtration); [0003] In an affinity-based immunocapture approach, CTCs are positively selected using epithelial surface antigens (cell adhesion molecule EpCAM, epidermal growth factor receptor EGFR, and mucin 1), mesenchymal antigens (mesenchymal vimentin), and tissue-specific antigens. (including prostate-specific membrane antigen PSMA for prostate cancer cells and HER2 for breast cancer cells), in addition to cytokeratin CK and N-cadherin; CTC negative selection by antibodi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/12
CPCC12M33/14
Inventor 杨根韩锦涛
Owner 武汉生民医疗科技有限公司
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