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Methods of treatment and uses thereof

A technology of use and application method, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as difficulty in swallowing, restrictions, and aggravated lack of effective drugs

Pending Publication Date: 2022-05-10
EUSTRALIS PHARMA LIMITED TRADING AS PRESSURA NEURO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] TBI patients may lose consciousness or have trouble swallowing, further exacerbating the lack of effective drugs
Therefore, there are limitations on how the drug can be administered

Method used

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  • Methods of treatment and uses thereof
  • Methods of treatment and uses thereof
  • Methods of treatment and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0098] Compounds of formula (I), especially compound (Ia) as shown below, especially the dihydrochloride salt of compound (Ia) (compound (Ia) HCl), were used in all examples.

[0099]

[0100] (designated here as "EUC-001")

[0101] Solubility

[0102] Table 3 shows the solubility assessment of Compound (Ia) and its respective pH. Ethanol was also evaluated as part of this study. The API was readily soluble at a compound (Ia) HCl concentration of 50 mg / mL, and a golden yellow color was observed.

[0103] Table 3: Solubility of Compound (Ia) 2HCl in Water

[0104]

[0105] EU-C-001 was formulated as a stock solution consisting of 15 mg / ml EU-C-001 in 80% propylene glycol and 20% water for injection, and the pH was adjusted to 4.5-5.5 with sodium hydroxide. The placebo stock solution is the same without active substance. The stock solution was filled into vials containing 7.5 ml. For administration, 6 ml of the stock solution (90 mg) was injected into a commerciall...

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PUM

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Abstract

The present invention relates generally to methods of treatment including delivery of specific substituted pyridyl compounds to reduce intracranial pressure (ICP) to treat P substance mediated pathways in the brain, such as, but not limited to, brain concussion, post-concussion (or post-concussion) syndrome (PCS), chronic traumatic encephalopathy (CTE), traumatic brain injury (TBI), and stroke.

Description

technical field [0001] The present invention relates generally to methods of treatment involving the delivery of specific substituted pyridyl compounds to lower intracranial pressure (ICP) for the treatment of substance P-mediated pathways in the brain, such as but not limited to concussion, post-concussion (or post-concussion ) syndrome (PCS), chronic traumatic encephalopathy (CTE), traumatic brain injury (TBI) and stroke. Background technique [0002] Traumatic brain injury (TBI), also known as an intracranial injury, occurs when an external force injures the brain. TBI can be classified according to severity, mechanism (closed or penetrating brain injury), or other characteristics (eg, occurrence in a specific location or broad area). TBI can cause physical, cognitive, social, emotional, and behavioral symptoms, and its outcome can range from complete recovery to permanent disability or death. [0003] TBI occurs as a result of sudden acceleration or deceleration within...

Claims

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Application Information

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IPC IPC(8): A61P25/00A61K31/496A61K9/08
CPCA61P25/00A61K31/496A61K9/0019A61P1/08A61K47/10A61K9/08
Inventor P·万坎P·帕西
Owner EUSTRALIS PHARMA LIMITED TRADING AS PRESSURA NEURO