Electrospray excitation device and ionization method

An electrospray ionization and electrospray technology is applied in the field of photobiochemical analysis to achieve the effects of high sensitivity, strong stability and simple operation steps.

Pending Publication Date: 2022-05-13
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Abstract
  • Description
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But the first technology requires a special power supply, and the second technology requires fine electrode placement site requirements

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  • Electrospray excitation device and ionization method
  • Electrospray excitation device and ionization method
  • Electrospray excitation device and ionization method

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Embodiment Construction

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below, obviously, the described embodiments are only some of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0025] In order to make the purpose, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the invention.

[0026] The present invention will be described further in conjunction with accompanying drawing now.

[0027] An electrospray excitation method, usi...

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Abstract

The invention discloses an electrospray excitation device and an ionization method, relates to the technical field of mass spectrometry, and utilizes a charge generation device to induce a capillary tube to generate electrospray. Specifically, a conductive coating material is used for collecting charges generated by a charge generation module, and the charges act on a spray capillary tube, so that a solvent is subjected to electrospray ionization to generate ions which enter a mass spectrometer for detection. Electro-spray can be generated under the condition that high pressure is not in contact with a spray solvent, and electrochemical side reaction and redox reaction of an analyte caused by contact of an electrode and the solvent are effectively avoided. Meanwhile, the flow velocity of the electrospray can be as low as picoliter level, the analysis time of an ultramicro sample can be long enough, and abundant mass spectrum signals can be collected. The method has the advantages of simple operation steps, high sensitivity and strong stability.

Description

technical field [0001] The invention relates to the technical field of photobiochemical analysis, in particular to an electrospray excitation device and an ionization method. Background technique [0002] Conventional electrospray devices use a method in which a high-voltage electrode is in contact with a spray solvent to generate electrospray, which is accompanied by electrochemical reactions around the electrodes and redox reactions of some analytes, making the mass spectrum more complex. In addition, ionization techniques in which the electrode is in contact with the spray solvent, such as nanoliter electrospray, have a flow rate in the nanoliter range, and the acquisition time is too short to collect enough compounds for the analysis of picoliter samples such as single-cell level analysis. Mass Spectrum Information. [0003] Existing electrospray devices that isolate high voltage from the spray solvent mainly include pulsed high voltage induced nanoliter electrospray 1 ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/16
CPCH01J49/165H01J49/167
Inventor 周燕夏兵王宇
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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