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Method for preparing medicine for recovering mitochondrial homeostasis and application thereof

A mitochondrial and steady-state technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as unreported, restore mitochondrial homeostasis, and achieve the effect of low toxic side effects and abundant drug sources.

Pending Publication Date: 2022-05-27
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current research on the recovery of alcoholic fatty liver function mainly focuses on the changes of mitochondria itself, such as unilaterally enhancing autophagy, or increasing mitochondrial biogenesis, which can only partially improve the function, but how to restore the homeostasis of mitochondria has not been reported

Method used

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  • Method for preparing medicine for recovering mitochondrial homeostasis and application thereof
  • Method for preparing medicine for recovering mitochondrial homeostasis and application thereof
  • Method for preparing medicine for recovering mitochondrial homeostasis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The modeling software modeled the Gao-Binge model, and the whole process was isocalorically fed with an alcoholic liquid feed for a total of 16 days. Alcohol liquid feed was purchased from Nantong Trofe Feed Technology Co., Ltd. (Item No.: TP4030C, TP4030D). The first day to the fifth day was the adaptation period. During this period, the alcohol concentration in the diet of the model group increased sequentially from low to high. The 6th to 16th day is the modeling period. On the 16th day, the model group was given an alcohol gavage around 8:00 a.m., and the control group was given dextrin by gavage. The modeling process is over. Feeding and modeling process such as figure 1 shown.

[0039] After the modeling process, that is, from the 17th day, the mice were injected with rapamycin (2 mg / kg) intraperitoneally around 9 am every day, and DMF (10 mg / kg) was injected intraperitoneally into the mice at about 5 pm every day. Inject 2 consecutive weeks.

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Abstract

The invention discloses a method for recovering mitochondrial homeostasis. The method is characterized in that one or two of antibiotics or DMF (Dimethyl Formamide) are injected at the same time. Under the condition that selected antibiotics are appropriate, the traditional Chinese medicine composition has the effect of being wide in source, meanwhile, the invention provides a good health care method for the liver, and meanwhile, the traditional Chinese medicine composition has the effect of providing thoughts for treatment of other autophagosome related diseases.

Description

technical field [0001] The invention belongs to the technical field of health care products, in particular to a method for preparing a medicine for restoring mitochondrial homeostasis and its application. Background technique [0002] As an important metabolic organ of the human body, the liver is highly susceptible to external influences, such as viral infections, alcohol, obesity, high-fat foods, genetic mutations, and illegal drug injections, which can all cause liver diseases. According to liver damage, it can be divided into five types: mild AFLD, alcoholic fatty liver disease, alcoholic hepatitis, alcoholic liver fibrosis and alcoholic liver cirrhosis. [0003] Modern people generally have more drinking habits and preferences than ancient people. The main site of alcohol metabolism is the liver. Long-term intake of large amounts of alcoholic beverages makes the liver exceed the normal physiological metabolism and detoxification ability, resulting in many important phys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/436A61P43/00A61P1/16A61K31/225
CPCA61K31/436A61K31/225A61P43/00A61P1/16
Inventor 龚国华李安琪
Owner TONGJI UNIV
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