Medicine for preventing or treating hypertension accompanied by depression and application thereof

Abstract

The invention relates to the technical field of medicine, in particular to a medicine for preventing or treating hypertension accompanied by depression and application of the medicine, the medicine comprises ginsenoside and hydroxybutyric acid, and the mass ratio of the ginsenoside to the hydroxybutyric acid can be 102: 4-73: 8. According to the application disclosed by the invention, a clinical common depression treatment drug fluoxetine and a hypertension drug captopril are taken as positive controls, an experimental research on the treatment effect of ginsenoside and hydroxybutyric acid on rats with depression accompanied by hypertension is developed, and a research result shows that the ginsenoside and hydroxybutyric acid composition remarkably reduces the depression-like behavior and hypertension level of the rats.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for preventing or treating high blood pressure accompanied by depression and its application. Background technique [0002] Depression is a common mental disease. With the development of social economy and the increase of work and life pressure, the number of patients with depression is increasing year by year. According to data provided by the World Health Organization, 10 to 20 million people worldwide have suicide attempts every year, of which about 70% suffer from depression [Olesen J, Gustavsson A, Svensson M, et al. The economic cost of brain disorders in Europe. Eur J Neurol. 2012, 19:155-162]. Depression, also known as depressive disorder, is a neuropsychiatric disease characterized by significant and persistent depression as the main clinical feature. Its clinical manifestations include depression, anorexia, anhedonia, social anxiety, etc. KT. Depression in...

AI Technical Summary

Problems solved by technology

The treatment of depression associated with hypertension includes conventional antidepressant and antihypertensive treatment, but there are relatively few drug choices, large adverse reactions, poor tolerance, high cost and other problems. More seriously, some antidepressants can aggravate hypertension Symptoms, such as higher systolic and diastolic blood pressure and a higher incidence of clinical grade 1 or 2 hypertension in patients who had previously received a tricyclic antidepressant (TCA) compared with healthy controls and treatment-naïve patients [C.M.Licht, E.J.de Geus, et al. Depression is associated with decreased blood pressure, but antidepressant use increases the risk for hypertension. Hypertens, 53(4)(2009), pp.631-638]

However, there is no report on the combination of ginsenoside Rh2 and β-hydroxybutyric acid in the treatment of depression associated with hypertension

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