Xanthene compound and preparation method thereof
A compound and heteroatom technology, applied in the field of xanthene compounds and their preparation, can solve the problem of single preparation method of xanthene compounds, and achieve the effect of novel structure and high yield
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Embodiment 1
[0068]
[0069] Synthesis of compound 3:
[0070] Compound 1 (10.0 g, 2.0 eq) and compound 2 (4.2 g, 1.0 eq) were added to a 150 mL sealed tube, followed by 30 mL of methanesulfonic acid, under nitrogen atmosphere, tighten the stopper, and place the reaction vial in 150°C oil The reaction was carried out in the bath for 16h. Stop heating to room temperature, slowly add the reaction dropwise to 600 mL of ice water, and stir while adding. After the dropwise addition, slowly add 4M sodium hydroxide dropwise to adjust the pH of the solution to 7. At this time, the color of the reaction solution changes from red to Purple, and a large amount of solid was precipitated, suction filtration to obtain a solid, which was placed on a rotary evaporator, and excess water was removed under reduced pressure to obtain 20 g of purple compound 3 (crude product) with a purity of 55%.
[0071] Synthesis of compound 4:
[0072] The prepared compound 3 (20.0g, 1.0eq) was added to a 250mL single...
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