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Use of angelica polysacchavide and sodium ferulate composition in preparation of analgesic

A technology of sodium ferulate and its composition, which is applied in the application field of preparing analgesic drugs with the composition of angelica polysaccharide and sodium ferulate, which can solve the problems of unclear active ingredients and achieve remarkable effects

Inactive Publication Date: 2003-08-06
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether the water-soluble part of Angelica sinensis has analgesic effect has not been reported, and the active ingredients of Angelica sinensis that exert analgesic effect are still unclear

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: Angelica polysaccharide and sodium ferulate composition prepares the medicine for treating analgesia: the polysaccharide of Angelica sinensis of 1% (percentage by weight) and the sodium ferulate of 99% (percentage by weight) are mixed and added excipient, according to routine Method made into tablets.

Embodiment 2

[0010] Embodiment 2: Angelica polysaccharide and sodium ferulate composition prepares the medicine for treating analgesia: the polysaccharide of Angelica sinensis of 50% (percentage by weight) and the sodium ferulate of 50% (percentage by weight) are mixed and added excipient, according to routine Method made into capsules.

Embodiment 3

[0011] Embodiment 3: Angelica polysaccharide and sodium ferulate composition prepares the medicine for treating analgesia: the angelica polysaccharide of 99% (percentage by weight) and the sodium ferulate of 1% (percentage by weight) are mixed by 1: 1 (v / v) adding water for injection, and making an injection according to a conventional method. 1. The effect experiment of the composition of Angelica polysaccharide and sodium ferulate on the writhing response of female mice induced by acetic acid, the pain model. The results are shown in Table 1.

[0012] Table 1 The effect of the composition of Angelica polysaccharide and sodium ferulate on the writhing reaction induced by acetic acid. N (number of cases) = 10, x ± s (mean ± standard deviation)

[0013] writhing reaction

[0014] Grouping dose (mg kg -1 )

[0015] Latency period (min) Times (times / 30min) Protection rate (%)

[0016] Model ...

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PUM

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Abstract

The present invention relates to an application of angelica polysaccharide and sodium ferulate compositino in preparation of analgesic with obvious action for stopping pain and obvious therapeutic effect for curing "dysmenorrhea". Said medicine can be made into capsule, tablet, granules preparation and injection preparation.

Description

technical field [0001] The invention relates to the application of the composition of angelica polysaccharide and sodium ferulate as an analgesic. Background technique [0002] Angelica belongs to tonic medicine, which is the dry root of Angelica sinensis (Oliv).Diels, a perennial herb belonging to the umbrella family (umbuiferae). Angelica has the effects of enriching blood and blood, promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain. Clinically, angelica is often used in combination with other medicines for irregular menstruation, dysmenorrhea, blood deficiency headache, waist and abdomen pain and other diseases. [0003] The chemical composition of angelica includes two major parts of volatile oil and water-soluble components. Early studies have pointed out that angelica oil has a relaxing effect on isolated uteri of various animals, both pregnant and non-pregnant. It partly explains the use of Angelica sinensis in the tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P29/00
Inventor 彭仁琇乐江汪晖孔锐
Owner WUHAN UNIV
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