The invention provides an external medicine for treating herpes zoster neuralgia. The external medicine is characterized by being prepared from the extracts of the following raw materials in parts by weight: 30 parts of radix zanthoxyli, 60 parts of paris polyphylla, 9 parts of mint, 9 parts of borneol, 30 parts of fructus forsythiae, 50 parts of sophora flavescens, 40 parts of prunella vulgaris, 30 parts of isatis root, 20 parts of raw licorice, 30 parts of black soya bean, 60 parts of rhizoma pleionis, 45 parts of knoxia root, 30 parts of semen euphorbiae, 30 parts of Chinese gall, 9 parts of musk, 6 parts of realgar, 1 part of sodium ferulate, 1 part of acyclovir, 10 parts of vitamin C, and 0.005 part of vitamin B12. The external medicine is developed on the basis of western medicine and traditional Chinese medicine; the western medicine and traditional Chinese medicine are used together, the functions of western medicine and traditional Chinese medicine are fully exerted; the external medicine can prevent virus, promote tissue recovery, reduce exudation of herpes, absorb percolate of herpes, relieve pain, and promote the recovery of function of peripheral nerve, the cure rate and effective rate are high, the virus replication can be inhibited rapidly, the neuralgia caused by herpes can be relieved, and the curative effect is prominently better than that of conventional drugs.