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Sodium ferulate oral disintegrating tablet and its preparation process

A sodium ferulate and free radical technology, applied in the field of sodium ferulate orally disintegrating tablet preparations, can solve the problems of great pain for patients, difficulty in taking it, high manufacturing and medical costs, etc.

Active Publication Date: 2005-07-06
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the dosage form, most oral preparations need to be taken with a lot of water, which makes it difficult for many elderly people, infants, or patients with difficulty swallowing and inconvenient water intake.
Injections are often prone to allergic reactions or adverse reactions, etc. At the same time, injections also have the disadvantages of difficult operation, great pain for patients, high manufacturing and medical costs, and heavy economic burden for patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment one direct flavoring method

[0036] 1. Prescription

[0037] 1. Raw material - sodium ferulate 50.0g;

[0038] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;

[0039] 3. Filling agent - mannitol 78.5g;

[0040] PROSOLV  SMCC 5.0g;

[0041] 4. Flavoring agent - aspartame 1.0g;

[0042] Ginseng essence 1.0g;

[0043] 5. Disintegrant—cross-linked polyvinylpyrrolidone 8.0g;

[0044] L-HPC 4.0g;

[0045] 6. Glidant—micronized silica gel 1.0g;

[0046] 7. Lubricant—magnesium stearate 1.0g.

[0047] A total of 1000 tablets were made, specification: 50mg / tablet.

[0048] 2. Preparation method

[0049]1) Take the sodium ferulate raw material and pulverize it, granulate it with polyvinylpyrrolidone K-30, pass it through a 26-mesh sieve, and set aside;

[0050] 2) Micropowder silica gel, ginseng essence, PROSOLV  SMCC and aspartame were passed through a 40-mesh sieve, mixed evenly, and then the granulated sodium ferulat...

Embodiment 2

[0053] Example 2 Powder coating taste masking method

[0054] 1. Prescription

[0055] 1. Raw material - sodium ferulate 50.0g;

[0056] 2. Coating material——Eudragit  E100 7.0g;

[0057] Eudragit  NE30D (dry) 3.0g;

[0058] 3. Filling agent - mannitol 90.0g;

[0059] Microcrystalline cellulose 10.0g;

[0060] 4. Flavoring agent - aspartame 1.0g;

[0061] Ginseng essence 1.0g;

[0062] 5. Disintegrant—cross-linked polyvinylpyrrolidone 10.0g;

[0063] L—HPC 5.0g;

[0064] 6. Glidant—micronized silica gel 1.0g;

[0065] 7. Lubricant—sodium stearyl fumarate 1.0g.

[0066] A total of 1000 tablets were made, specification: 50mg / tablet.

[0067] 2. Preparation method

[0068] 1) Take Eudragit  E100 and Eudragit  NE30D Eudragit  NE30D is dissolved in 95% ethanol and diluted to a certain concentration for later use;

[0069] 2) Take sodium ferulate and place it in an ebullating bed for boiling, spray the above-menti...

Embodiment 3

[0072] Embodiment three effervescent agent flavoring method

[0073] 1. Prescription

[0074] 1. Raw material - sodium ferulate 50.0g;

[0075] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;

[0076] 3. Effervescent agent - citric acid 15.5g;

[0077] Sodium bicarbonate 12.0g;

[0078] 4. Filling agent - mannitol 48.0g;

[0079] PROSOLV  SMCC 5.0g;

[0080] 5. Flavoring agent - aspartame 1.0g;

[0081] Orange essence 1.0g;

[0082] 6. Disintegrant—cross-linked polyvinylpyrrolidone 10.0g;

[0083] L-HPC 5.0g;

[0084] 7. Glidant - micronized silica gel 1.0g;

[0085] 8. Lubricant—sodium stearyl fumarate 1.0g.

[0086] A total of 1000 tablets were made, specification: 50mg / tablet.

[0087] 2. Preparation method

[0088] 1) Mix sodium ferulate and citric acid raw materials and pulverize them, granulate with polyvinylpyrrolidone K-30, pass through a 26-mesh sieve, and set aside;

[0089] 2) Take sodium bicarbonate and p...

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Abstract

The invention discloses a sodium ferulate orally disintegrating tablet and its preparation, wherein the tablet is prepared by using sodium ferulate as raw material, using bulking agent, crumbling agent, flavoring agent, flow aid, and lubricating agent as adjuvant, using bonding agent or dressing material based on specific situation, or charging right amount of effervescent agent, then using specific preparing procedure and employing a tablet compressing machine for pelleting. The invention realizes quick disintegrating speed, good taste, the tablet can be taken under the condition of waterless, it has the advantages of fast effect, improved compliance for the patients, and increased curative effect of the medicament.

Description

technical field [0001] The invention relates to a kind of anti-oxidation and free radical scavenging effect, which can protect the cell membrane from oxidation and inhibit platelet aggregation and thrombus formation, and is clinically used for anti-atherosclerosis, treatment of vascular embolism vasculitis, acute cerebral thrombosis and partial hemorrhage Sodium ferulate orally disintegrating tablet preparation for headache and other symptoms. Background technique [0002] Sodium ferulate is the sodium salt of ferulic acid, the main component of the traditional traditional Chinese medicine for promoting blood circulation and removing blood stasis, Angelica and Chuanxiong. The chemical name is: 3-methoxy-4-hydroxycinnamic acid sodium salt dihydrate, also known as angelica element, etc. [0003] Sodium ferulate is a non-peptide endothelin receptor antagonist, which has various pharmacological effects: it can antagonize endothelin-induced vasoconstriction, blood pressure and va...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/192A61P7/02A61P9/10A61P9/14A61P25/04A61P39/06
Inventor 蒋海松王锦刚王红喜
Owner COSCI MED TECH CO LTD
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