Application of sodium ferulate in preparation of medicaments for treating schizophrenia

A schizophrenia, sodium ferulate technology, applied in the field of medicine, can solve problems such as weight gain, poor patient compliance, and affecting long-term treatment value

Inactive Publication Date: 2012-12-26
赵宏杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Typical anti-spermia drugs are also called traditional anti-spermia drugs, representative drugs include chlorpromazine, haloperidol, etc. These drugs are effective in treating positive symptoms, but are ineffective for negative symptoms, and the treatment is often accompanied by severe symptoms. Extrapyramidal reactions (EPS), poor patient compliance
Atypical antispermia drugs, also known as non-traditional antispermia drugs, have a wider therapeutic spectrum and are significantly better than traditional drugs for negative symptoms. They have less side effects in the short term, but long-term use can lead to weight gain, abnormal lipid and glucose metabolism trends increase, thus affecting the long-term therapeutic value, the increase of serum prolactin and the prolongation of Q-T interval will also seriously affect the quality of life of patients; reduce the compliance of taking

Method used

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  • Application of sodium ferulate in preparation of medicaments for treating schizophrenia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Preparation of medicament for treating schizophrenia by sodium ferulate: add sodium ferulate to excipients, and make tablets according to conventional methods.

Embodiment 2

[0015] Example 2: Sodium ferulate prepares medicine for treating schizophrenia: add sodium ferulate to water for injection, and make an injection according to a conventional method.

[0016] Clinical observation 1:

[0017] 1 Objects and methods

[0018] 1.1 Subject cases 46 patients were selected, in line with CCMD-2-R diagnostic criteria for schizophrenia, Brief Psychiatric Scale (BPRS) > 35, male: female (24:22), average age (32.4 ± 6. 8) years old, the average course of disease (2.8 ± 3.2) years.

[0019] 1.2 Methods Randomly divided into treatment group and control group. The treatment group received 500 mg of sodium ferulate and 250 ml of 5% glucose intravenously. The control group received 250ml of 0.9% sodium chloride intravenously. 25 days is a course of treatment. There were 24 cases in the treatment group and 22 cases in the control group. Before and after treatment, the two groups were scored by BPRS.

[0020] Statistical processing SPSS 13.0 software p...

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PUM

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Abstract

The invention relates to the technical field of pharmaceuticals, and in particular relates to an application of sodium ferulate in preparation of medicaments for treating schizophrenia. The medicament treatment for schizophrenia has a plurality of problems of large medicament side effects, poor treatment compliance, high recurrence rate and high disability rate; and the large medicament side effects cause poor treatment compliance, high recurrence rate and high disability rate. The invention provides the technical scheme for solving the problems. When sodium ferulate is separately used, and is particularly used for intravenous injection of sodium ferulate, so a corresponding curative effect with low side effects and high treatment compliance can be obtained. By combining with the existing medicaments, sodium ferulate is applied to reduce the side effects of the existing medicaments can be greatly reduced, and meanwhile, the same curative effect is obtained, so the medicaments or complementary medicaments for treating schizophrenia have a very bright prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to the application of sodium ferulate in preparing medicine for treating schizophrenia. Background technique [0002] Sodium ferulate is a water-soluble active ingredient extracted from angelica or chuanxiong, also known as angelica or chuanxiong. It has a wide range of pharmacological effects, and now it is mainly artificially synthesized. The chemical name is 3-methoxy-4-hydroxycinnamic acid Sodium has pharmacological effects such as anti-platelet aggregation, inhibiting the release of platelet 5-hydroxytryptamine, inhibiting the generation of platelet thromboxane a2 (txa2), enhancing the activity of prostaglandins, analgesic, and relieving vasospasm. At present, sodium ferulate is mainly used for atherosclerosis, coronary heart disease, cerebrovascular disease, glomerular disease, pulmonary hypertension, diabetic vascular disease, vasculitis, migraine, vascular headache and other ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P25/18
Inventor 赵宏杰
Owner 赵宏杰
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