Slow-release enteric-coated sodium ferulate preparation and preparation method thereof

A technology of sodium ferulate and slow-release preparations, which is applied in the field of pharmaceutical preparations, can solve the problems of poor stability, great influence on stability, and low bioavailability of ordinary tablets, so as to improve bioavailability, reduce the number of times of taking medicine, Guarantee the effect of drug safety
CN106176684AInactive Publication Date: 2016-12-07HYBIO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HYBIO PHARMA
Publication Date
2016-12-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of pharmaceutical preparations, in particular to a sodium ferulate enteric-coated sustained-release preparation and a preparation method thereof. The invention provides an enteric-coated sustained-release preparation of sodium ferulate, comprising the following raw materials in parts by mass: 30-50 parts of sodium ferulate, 20-40 parts of sustained-release materials, 3-10 parts of enteric-coated materials, pharmaceutically 10-30 parts of acceptable excipients. The present invention adopts the technology of enteric-coated sustained-release capsules. Compared with ordinary tablets, the technology of enteric-coated sustained-release capsules can maintain a stable blood drug concentration, avoid burst release effects, not disintegrate in the stomach, and reduce side effects. Medium-release medicine, improve bioavailability, take it orally once a day, reduce the number of times of taking medicine, and improve patient compliance. The prepared enteric-coated slow-release content is loaded in the capsule, avoiding the influence of antioxidants and alkali light, etc., and effectively improving the stability of the drug.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a sodium ferulate enteric-coated sustained-release preparation and a preparation method thereof. Background technique

[0002] Sodium ferulate is the sodium salt of ferulic acid, an effective monomer component extracted from the traditional Chinese medicine Angelica sinensis and Chuanqiong. -Hydroxycinnamic acid sodium salt dihydrate, molecular formula: C 10 h 9 NaO 4 2H 2 O. Ferulic acid is a vascular endothelial protective agent, which can scavenge free radicals, prevent lipid peroxidation damage, antagonize endothelin-induced vasoconstriction, boost blood pressure and vascular smooth muscle cell proliferation, reduce vascular endothelial damage; increase NO synthesis, relax vascular smooth muscle ; Inhibit platelet aggregation, anticoagulation, improve hemorheology characteristics. It can also inhibit the synthesis of cholesterol, lower blood lipids, affect com...

Claims

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