Application of sodium ferulic acid in preparing medicament for expanding vascellum

A technology of sodium ferulate and vasodilator, applied in the application field of sodium ferulate in the preparation of vasodilators, can solve problems such as unclear sodium ferulate, and achieve the effect of expanding the scope of medicinal use

Inactive Publication Date: 2008-07-16
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, it is not clear whether sodium ferulate can be used alone as a vasomodulatory drug for the treatment of heart, brain, kidney, limbs and other vascular complications and / or comorbidities

Method used

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  • Application of sodium ferulic acid in preparing medicament for expanding vascellum
  • Application of sodium ferulic acid in preparing medicament for expanding vascellum
  • Application of sodium ferulic acid in preparing medicament for expanding vascellum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Preparation of Rat Isolated Aortic Ring

[0019] 1. Experimental drug

[0020] Sodium ferulate is provided by Hangzhou Zhongxiang Chemical Co., Ltd., and its properties are white powder, odorless, and its purity is 99.54%. Dissolve with Krebs-Henseleit (K-H) solution immediately before use.

[0021] 2. Experimental steps

[0022] Clean grade male Sprague-Dawley (SD) rats, weighing 250-300g.

[0023] Rapidly dissociate the thoracic aorta of SD rats and place at 4°C containing 95% O 2 and 5% CO 2 In the K-H liquid pre-saturated with mixed gas, the surrounding connective tissue was removed and cut into vascular rings of 3-4 mm. During this period, care should be taken to protect the intima of the vascular rings from damage. According to the needs of the experiment, the method of rubbing the inner surface of the vascular ring with a cotton swab was used to prepare a part of the vascular ring as a model in which the endothelium was removed. Then the vascular ...

Embodiment 2

[0024] Example 2 Effect of Sodium Ferulate on the Relaxation and Contraction Function of the Isolated Aortic Ring

[0025] According to the method of embodiment 1, observe after the vascular ring is stable:

[0026] (1) The effect of sodium ferulate on the tension of PE or KCl pre-contracted vascular ring

[0027] 60mmol·L -1 KCl or 1μmol·L -1 PE pre-contracted the aortic ring of rats, using the cumulative dosing method, adding sodium ferulate once every 10 minutes, and observing the cumulative administration of 0.1-30 mmol·L sodium ferulate -1 Effects on endothelial integrity and endothelial removal of vascular rings; in the control group, K-H solution was added instead of sodium ferulate.

[0028] (2) The effect of sodium ferulate on the tension of phorbol ester preconstricted vascular ring

[0029] In calcium-free solution, at 1 μmol L -1 Pre-shrink the endothelium with phorbol ester to remove the aortic ring, add sodium ferulate 0.1-30 mmol·L every 10 min -1 , to obs...

Embodiment 3

[0032] Example 3 Effect of Sodium Ferulate on Contraction of Vascular Smooth Muscle Caused by Influx of Extracellular Calcium Ions

[0033] According to the above experimental results, it was found that when the concentration of sodium ferulate accumulated to 1, 3 and 10mmol·L -1 When , the change of its vascular tension is more obvious, so these three concentrations are selected for the next experiment. And according to the method of embodiment 1, observe after the vascular ring is stable:

[0034] (1) The voltage sensitivity of sodium ferulate to high concentration KCl-induced activation of Ca 2+ channel effect

[0035] In calcium-free solution, with high concentration KCl (60mmol·L -1 ) to incubate the endothelium to remove the aortic ring, and then use 1, 3 or 10mmol·L -1 Sodium ferulate pretreated the vascular ring for 10min, observed the effect of different concentrations of sodium ferulate on the accumulation of CaCl 2 (0.01~10mmol·L -1 ) caused by vasoconstrictio...

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PUM

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Abstract

The invention provides an application of sodium ferulate - an herb extract in the preparation of vasodilators, in particular to the application in the preparation of drugs for treating hypertension, stenocardia, etc. The sodium ferulate of the invention combined with the medical excipients permitted by the pharmacodynamics can be made into a preparation. The preparation forms essentially consist of liquid preparation and solid preparation, wherein, the solid preparation essentially consists of troche, capsule (soft capsule included) and guttate pill; the liquid preparation essentially consists of oral liquid preparation and injection liquid preparation. As the second development of the traditional herb extract-- sodium ferulate, the invention has the new pharmacological action of achieving arteriectasia directly, can relax the vascular smooth muscle, thus expanding the officinal scope, which can be used for preparing drugs to treat various relevant vascular anomalies.

Description

technical field [0001] The invention relates to the application of sodium ferulate, a traditional Chinese medicine extract, and mainly relates to the application of sodium ferulate in preparing vasodilators. It is suitable for the occasion of preparing antihypertensive drugs, and is also suitable for the occasion of preparing antiangina pectoris drugs. Background technique [0002] Hypertension is a common and frequently-occurring disease that seriously endangers human health. In my country, hypertension is the disease with the highest incidence rate among cardiovascular diseases. According to the 2002 Chinese Resident Nutrition and Health Survey and the results of three national health service surveys, there are 174 million hypertensive patients in my country, and about 220,000 people die of high blood pressure every year. According to the third sample survey in Zhejiang Province in 2003, the prevalence of hypertension in Zhejiang Province increased by 275% within 13 year...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P9/08
Inventor 胡申江陈国萍
Owner ZHEJIANG UNIV
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