Preparation method of sodium ferulate freeze dried powder injection

A technology for freeze-dried powder injection and sodium ferulate, which is applied in freeze-dried delivery, antidote, powder delivery, etc., and can solve the problem of high unqualified rate of clarity, poor product quality stability, and instability of sodium ferulate, etc. It can achieve good solubility, reduce vascular endothelial damage, and inhibit the synthesis of cholesterol.
CN1830427AInactive Publication Date: 2006-09-13巴里莫尔制药(通化)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
巴里莫尔制药(通化)有限公司
Publication Date
2006-09-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

A freeze-dried powder injection of sodium ferulate for treating atherosclerosis, coronary heart disease, cerebrovascular disease, glomerulus disease, pulmonary hypertension, vasculitis, etc is prepared from sodium ferulate through ultrafiltration, mixing with filtered mannitol in N2 atmosphere and dark condition, pouring in containers, freeze drying and sealing.
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Description

technical field

[0001] The present invention relates to a kind of preparation method of sodium ferulate freeze-dried powder injection, specifically, relate to a kind of freeze-dried powder injection with sodium ferulate as the main component, after sodium ferulate is processed by ultrafiltration technology, then It is prepared with mannitol filtrate under the condition of avoiding light and nitrogen gas, filled, freeze-dried, crimped and packaged to make a freeze-dried powder injection finished product, which belongs to the field of chemical preparations. It has been proved by clinical experiments that this product can be injected intravenously, can antagonize non-peptide endothelin receptors, can antagonize endothelin-induced vasoconstriction, boost blood pressure and proliferation of vascular smooth muscle cells, reduce vascular endothelial damage; increase NO synthesis, relax Vascular smooth muscle; inhibit platelet aggregation, anticoagulation, improve hemorheological char...

Claims

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