Ferulaic acid sodium drip pill and its preparation method

A technology of sodium ferulate and dropping method, applied in the directions of pill delivery, metabolic diseases, blood diseases, etc., can solve the problem of long disintegration time of sodium ferulate tablets, affecting the therapeutic effect, dissolution rate and dissolution of sodium ferulate problems such as low rate, to achieve the effects of convenience in carrying and taking, small pill volume, and improved dissolution rate and dissolution rate

Inactive Publication Date: 2004-05-05
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The disintegration time of sodium ferulate tablets is long, the dissolution rate and dissolution rate are low, and the proportion of excipients is relatively large. Children, th

Method used

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  • Ferulaic acid sodium drip pill and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0052] prescription:

[0053] Sodium Ferulate 5g

[0054] Macrogol 6000 15g

[0055] Makes 1000 capsules

[0056] Preparation method: Take the ultrafinely pulverized sodium ferulate powder and pass through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by dropping, dry, and have to.

example 2

[0058] prescription:

[0059] Sodium Ferulate 5g

[0060] Macrogol 4000 15g

[0061] Makes 1000 capsules

[0062] Preparation method: Take the ultrafinely pulverized sodium ferulate powder and pass through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by dropping, dry, that is have to.

example 3

[0064] prescription:

[0065] Sodium Ferulate 5g

[0066] Macrogol 6000 5g

[0067] Macrogol 4000 10g

[0068]Makes 1000 capsules

[0069] Preparation method: Take the fine powder of sodium ferulate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0070] 4. Example 4

[0071] prescription:

[0072] Sodium Ferulate 5g

[0073] Glyceryl monostearate 15g

[0074] Makes 1000 capsules

[0075] Preparation method: Take the fine powder of sodium ferulate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as a coolant, make pellets by dropping, dry, and obtain .

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PUM

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Abstract

A dripping pill of sodium ferulate and its superfine pulverizing process for preparing it are disclosed. Its advantages are high dissolving and disintegrating speed, high stripping percentage, quickly taking its curative effect and low cost.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular sodium ferulate dropping pills and a preparation method thereof. Background technique [0002] Sodium ferulate is a non-peptide endothelin receptor antagonist, which can antagonize endothelin-induced vasoconstriction, pressurization and vascular smooth muscle cell proliferation; increase the synthesis of NO, relax vascular smooth muscle, inhibit platelet aggregation, anticoagulation, Improve hemorheological characteristics. It can also inhibit the synthesis of cholesterol, reduce blood lipids, scavenge free radicals, prevent lipid peroxidation damage, affect complement, enhance immune function, and have certain analgesic and antispasmodic effects. [0003] Oral sodium ferulate elimination half-life (t 1 / 2β ) is 11.46min ± 3.2min, the plasma protein binding rate is 20.6%, the absorption is fast and complete, the distribution is rapid, it can pass through th...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/192A61P3/06A61P7/02A61P37/04
Inventor 钱进许军彭红李平刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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