Sodium ferulic acid albumin nano granular preparation and its preparing method

A technology of albumin nanoparticles and sodium ferulate, applied in the field of medicine, can solve problems such as residues, difficult purification of nanoparticles, limited reliability, etc., and achieve the effects of low cost, strong operability, and narrow particle size distribution

Inactive Publication Date: 2005-05-18
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing preparation of albumin nanoparticles adopts thermal denaturation emulsification method, which requires the use of organic solvents to remove oily residues and surfactants, which not only easily causes residues, but also brings difficulties to the purification of nanoparticles, and the particle size is difficult to control. Also not good for heat labile drugs
Another albumin nanoparticle prepared by the pH-aggregation method has a wide particle size distribution, and the pH value needs to be adjusted under salt-free conditions. However, it is well known that the glass electrode is reliable in measuring the pH value in the presence of high concentrations of proteins. limited sex

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 prepares sodium ferulate albumin nanoparticle preparation

[0040] Accurately weigh 25.0 mg of albumin, dissolve it in 4.0 ml of 10 mM NaCl aqueous solution, the pH value is 8.3. Then accurately weigh 12.5 mg of sodium ferulate and dissolve it in an aqueous albumin solution, and continuously add 11.0 ml of 95% ethanol at a rate of 0.5 ml / min under stirring at room temperature (300 rpm) to form sodium ferulate albumin nanoparticles. Add 29 μl of 8% glutaraldehyde aqueous solution to cross-link the microparticles, and stir for more than 12 hours at the same time during the cross-linking process. Detected by a laser light scattering instrument, the particle size of the obtained sodium ferulate albumin nanoparticles was 181.0 nm, and the particle size distribution was 86.3%. Observation under the electron microscope shows that the shape of the nanoparticles is more round and the particle size distribution is narrower. The obtained nanoparticle colloidal susp...

Embodiment 2

[0042] Accurately weigh 50.0 mg of albumin, dissolve it in 4.0 ml of distilled water, the pH value is 8.3. Then accurately weigh 12.5 mg of sodium ferulate and dissolve it in an aqueous albumin solution, and continuously add 8.0 ml of 95% ethanol at a rate of 0.5 ml / min under stirring at room temperature (300 rpm) to form sodium ferulate albumin nanoparticles. Then add 27 μl of 8% glutaraldehyde aqueous solution to cross-link the microparticles, and stir at the same time for more than 12 hours during the cross-linking process. Detected by a laser light scattering instrument, the particle size of the obtained sodium ferulate albumin nanoparticles was 191.4 nm, and the particle size distribution was 86.8%. Observation under the electron microscope shows that the shape of the nanoparticles is more round and the particle size distribution is narrower. The obtained nanoparticle colloidal suspension is slightly heated overnight to remove ethanol, and then freeze-dried by a convent...

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Abstract

The present invention relates to medicine technology, and is nano granular sodium ferulate-albumin preparation as one new preparation form of sodium ferulate and its preparation process. The nanometer granular sodium ferulate-albumin preparation may be prepared through freeze drying process and may be compounded into injection for intravenous injection. After the sodium ferulate carried in albumin carrier enters body circulation, the nanometer granule is adsorbed by plasma opsonin, distinguished and phagocytized by macrophage in liver and spleen and targeted to liver. The present invention has raised sodium ferulate concentration in pathologic change part and thus raised curative effect and reduced side effect.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to a new dosage form of sodium ferulate—a sodium ferulate albumin nanoparticle preparation and a preparation method thereof. Background technique: [0002] Sodium ferulate is a commonly used drug in clinical practice. It has been found through research that sodium ferulate has anti-hepatic fibrosis effects, but the existing dosage forms are mostly ordinary tablets, powders and aqueous solutions, etc. After the drug enters the body and is distributed throughout the body, it cannot be concentrated in The liver exerts curative effects, and even produces adverse reactions outside the liver. [0003] As a drug carrier, albumin nanoparticles are safe, non-toxic, non-immunogenic, biodegradable, and biocompatible. They have unique targeting, slow and controlled release, and drug protection. They are one of the focuses in the field of biomedicine . The so-called targeting means that after ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K38/38A61P1/16
Inventor 胡晋红苏华李凤前
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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