Method for preparing medicine composition contg. aspirin

A technology for aspirin and composition, applied in the field of composition preparation, can solve the problems of unstable aspirin, gastrointestinal tract irritation, restricted application and the like

Inactive Publication Date: 2006-03-29
BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The drug is an extremely valuable drug for the prevention and treatment of ischemic cerebrovascular diseases, such as transient ischemic attack, cerebral ischemic stroke, and cerebral arteriosclerosis, but unfortunately, aspirin is extremely unstable, and the general preparation When the method is preparing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] prescription:

[0017] Material name

Dosage (g)

aspirin

Vitamin B 1

Microcrystalline Cellulose PH101

lactose

citric acid

2% hypromellose in water

20

10

10

34

1

about 20

[0018] Material name

Dosage (g)

Sodium Ferulate

Cinnarizine

Microcrystalline Cellulose PH101

lactose

2% hypromellose in water

50

25

25

50

about 40

[0019] Preparation:

[0020] 1. Sodium ferulate, aspirin, cinnarizine, lactose, and citric acid were respectively crushed through a 100-mesh sieve, vitamin B 1 Pass through a 100-mesh sieve, and microcrystalline cellulose pass through a 80-mesh sieve, and set aside.

[0021] 2. Prepare 2% hypromellose aqueous solution as a binder respectively, and set aside.

[0022] 3. According to aspirin and vitamin B 1 The ratio of some prescription components, weigh aspirin and vitamin B respectively 1 , micr...

Embodiment 2

[0032] prescription:

[0033] Material name

Dosage (g)

aspirin

Vitamin B 1

Microcrystalline Cellulose PH101

lactose

citric acid

2% hypromellose in water

20

10

10

34

1

about 20

[0034] Material name

Dosage (g)

Sodium Ferulate

Cinnarizine

Microcrystalline Cellulose PH101

lactose

2% hypromellose in water

50

25

25

50

about 40

[0035] Preparation:

[0036] 1. Sodium ferulate, aspirin, cinnarizine, lactose, and citric acid were respectively crushed through a 100-mesh sieve, vitamin B 1 Pass through a 100-mesh sieve, and microcrystalline cellulose pass through a 80-mesh sieve, and set aside.

[0037] 2. Prepare 2% hypromellose aqueous solution as a binder respectively, and set aside.

[0038] 3. According to aspirin and vitamin B 1 The ratio of some prescription components, weigh aspirin and vitamin B respectively 1 , micr...

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PUM

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Abstract

A process for preparing a compound containing aspirin to improve the stability of aspirin includes such steps as proportionally mixing aspirin, VB1 and auxiliary, pilling or granulating, proportionally mixing sodium ferulate with cinnarizine, pilling or granulating, mixing the prepared pills or particles loading in capsules or tabletting.

Description

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Claims

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Application Information

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IPC IPC(8): A61K31/616A61K9/48A61P9/10A61K31/192A61K31/51A61K31/495
Inventor 马希正李艳友
Owner BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
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