Dripping pills of tetrahydropalmatini sulfas and its preparation process

A technology of tetrahydropalmatine and sulfuric acid, which is applied in the direction of pharmaceutical formula, pill delivery, and medical preparations containing active ingredients, etc., which can solve the problem of large differences in pill weight, quality indicators, poor rounding rate of qualified products, and increased patient medication. Cost and other issues, to achieve the effect of small difference in pill weight, high rounding rate, and improved bioavailability

Inactive Publication Date: 2006-02-08
COSCI MED TECH CO LTD
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Problems solved by technology

[0009] Application number is the Chinese patent of invention of 03157889.6, also discloses a kind of tetrahydropalmatine dripping pills in its open description, but the tetrahydropalmatine sulfate dripping pills prepared according to the preparation method disclosed in the above-mentioned prior art, In the test, the qualified product of its rounding rate is relatively poor, and the difference in pill weight is also quite different from the quality indicators of the relevant drop pill preparations stipulated in the national drug standards. Such products affect the dosage to a certain extent in use. The accuracy of the product also reduces the qualified rate of the product in production, increases the production cost, and indirectly increases the drug cost of the patient, thus reducing its practicability

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  • Dripping pills of tetrahydropalmatini sulfas and its preparation process

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Embodiment Construction

[0031] Now with several groups of specific examples, the preparation method of Tetrahydropalmatine Sulfate Dropping Pills of the present invention will be further described.

[0032] [Test prescription]

[0033] 1. Raw material - tetrahydropalmatine sulfate

[0034] 2. Base—a mixture of polyoxyl 40 stearate and polyethylene glycol, as follows:

[0035] 2.1 Polyoxyl 40 stearate: polyethylene glycol 2000 =1:1~1:10

[0036] 2.2 Polyoxyl 40 stearate: polyethylene glycol 4000 =1:1~1:10

[0037] 2.3 Polyoxyl 40 stearate: polyethylene glycol 6000 =1:1~1:10

[0038] 2.4 Polyoxyl 40 stearate: polyethylene glycol 10000 =1:1~1:10

[0039]2.5 Polyoxyl 40 stearate: polyethylene glycol 20000 =1:1~1:10

[0040] 3. The ratio of tetrahydropalmatine sulfate and matrix:

[0041] In g or kg, tetrahydropalmatine sulfate: substrate = 1:1~1:9

[0042] 4. Prepare according to the process of [Preparation Method] 4-7 ​​to obtain tetrahydropalmatine sulfate dripping pills of different specif...

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Abstract

Dripping pills of tetrahydropalmatini sulfas and its preparation process, wherein the pills are prepared from tetrahydropalmatini as raw material, and polyethylene glycol, polyoxyl (40) stearate as base material.

Description

technical field [0001] The invention relates to a pharmaceutical composition for analgesia, in particular to an oral preparation of a pharmaceutical composition prepared from tetrahydropalmatine sulfate as a raw material. Background technique [0002] Dl-tetrahydropalmatine (dl-THP) is an alkaloid extracted from the traditional Chinese medicine Corydalis Corydalis. -THP, also known as craniotidine). Both have been used clinically as analgesic and sedative drugs. The analgesic mechanism of Dl-THP is explained from traditional Chinese medicine as "activating blood and promoting Qi". According to current pharmacological studies, 1-THP is related to blocking central dopamine (DA) receptors. Its analgesic effect is weaker than pethidine, but stronger than general antipyretic analgesics, better for chronic persistent pain, less effective for trauma and postoperative pain. In addition to the analgesic effect, there are obvious sedative and hypnotic effects. The biggest advantag...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61K9/20A61P25/04
Inventor 王锦刚
Owner COSCI MED TECH CO LTD
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