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A kind of sildenafil dripping pill

A technology of sildenafil and non-dropping pills, which is applied in the field of sildenafil dropping pills and its preparation, can solve the problems of low drug loading, poor pill shape, and difficulty in making dripping pills, and achieve bioavailability High, good formability, high rounding rate effect

Active Publication Date: 2021-11-30
JIANGSU TASLY DIYI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The excipients disclosed in the disclosed examples also have the problems of low drug loading or difficulty in dripping pills, and poor pill shape.

Method used

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  • A kind of sildenafil dripping pill
  • A kind of sildenafil dripping pill
  • A kind of sildenafil dripping pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] Prescription: raw material 14.04g; PEG400 12g; PEG4000 12g; sucrose 3g; Nacl 1.2g; water 2g

Embodiment 2

[0163] Prescription: raw material 14.04g; PEG400 10g; PEG4000 14g; sodium carboxymethyl starch 0.5g; Nacl 0.6g; microcrystalline cellulose 0.1g; sucrose 0.5g

Embodiment 3

[0165] Prescription: raw material 7.02g; PEG400 10g; PEG6000 15g; Nacl 5g

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Abstract

The invention relates to a sildenafil dropping pill, which is made of the following raw materials in weight percentage: 5-50% of sildenafil; 20-70% of a matrix, 0.1-20% of auxiliary materials that can increase cohesion, and improve dropping pills Properties and bioavailability-enhancing excipients 0-20%. The dropping pill has the function of treating erectile dysfunction.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation of chemical medicine and its preparation, in particular to a sildenafil dropping pill and its preparation. Background technique: [0002] Sildenafil citrate (sildenafil for short) is an oral drug for the treatment of erectile dysfunction (ED). It is the citrate salt of sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5) specific for cyclic guanosine monophosphate (cGMP). Mechanism of action: The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. The activation of guanylate cyclase by NO leads to an increase in the level of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscle in the cavernous body and fills the blood. Sildenafil citrate is a white to off-white crystalline powder with a very bitter taste. Its marketed dosage form, Sildenafil Citrate Tablets, is a special oral dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/26A61K47/36A61K47/02A61K47/12A61K47/14A61K47/10A61K47/38A61K31/519A61P15/10
CPCA61K9/2009A61K9/2013A61K9/2018A61K9/2031A61K9/205A61K9/2054A61K31/519
Inventor 孙鹤王国成陈莹
Owner JIANGSU TASLY DIYI PHARMA CO LTD
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