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Preventives/remedies for snore or respiratory disturbances during sleep

A technology for breathing disorders and therapeutic agents, applied in the field of food and feed, to solve problems such as unconfirmed effectiveness

Active Publication Date: 2006-06-21
AJINOMOTO CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, glutamic acid or glycine antagonists having the above-mentioned medicinal effects have not been used clinically, and their effectiveness in humans has not yet been confirmed.

Method used

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  • Preventives/remedies for snore or respiratory disturbances during sleep
  • Preventives/remedies for snore or respiratory disturbances during sleep
  • Preventives/remedies for snore or respiratory disturbances during sleep

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Glycine tablets and tablets containing L-cystine as an amino acid other than glycine (hereinafter referred to as control tablets) were taken before bedtime, and family members evaluated the snoring of the subjects during bedtime. In addition, sleep apnea and arterial oxygen saturation (SpO 2 ) for evaluation. The subject is a 38-year-old healthy male (weight 82kg, height 170cm, body mass index (BMI) 28.3), whose family members observed frequent apnea during bedtime. The subjects did not take any drugs for a long time, nor did they have the habit of taking nutritional supplements or nutritional supplements. In addition, during the test period, they did not take any drugs, nutritional supplements or nutritional supplements other than the glycine tablet and the control preparation. The subjects took an appropriate number (2-4 tablets) of glycine tablets or control tablets, and did not tell their family members about the types of these tablets and whether they had taken t...

Embodiment 2

[0132] In order to confirm the effect of glycine on sleep-related apnea, a double-blind crossover experiment was carried out, and 10 adult males with sleep apnea who had the following AHI (apnea-hypopnea index per hour) exceeding 5 were used as experimental subjects. conduct. Glycine 3 g was taken 1 hour before bedtime, and the placebo was reduced maltose adjusted so that no difference in taste was noticed.

[0133] (Assessment of hypopnea and apnea)

[0134] Sleep polygraph data (sleeppolygraph data) such as brain waves, electromyograms, and arterial oxygen saturation during sleep were measured using the Alice system manufactured by Respironics, Inc., USA. The airflow in the mouth and nose was measured, and when the time required for the state to drop below 50% to return to above 60% was longer than 10 seconds, it was defined as hypopnea. In addition, a decrease in arterial oxygen saturation of more than 3% associated with hypopnea is considered apnea. The sum of the numbe...

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PUM

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Abstract

The present invention provides an effective preventive and therapeutic agent for snoring or sleep-disordered breathing, and food and feed effective for preventing and alleviating snoring or sleep-disordered breathing. The present invention relates to a preventive and therapeutic agent for snoring or sleep-related breathing disorders, which contains a compound having an agonistic effect on glycine receptors as an active ingredient. The present invention also relates to a preventive and therapeutic agent for snoring or sleep-related breathing disorders, which contains as an active ingredient a compound that can exist in the form of glycine in a living body.

Description

technical field [0001] The present invention relates to a preventive and therapeutic agent for snoring or breathing disorder during sleep, and food and feed effective for preventing and alleviating snoring or breathing disorder during sleep. Background technique [0002] Snoring is caused by vibrating mucous membranes of the airway in the pharynx and the like accompanying airway narrowing or airway occlusion due to decreased muscle tension of the pharynx or tongue during sleep. The causes thereof include obesity, alcohol consumption, taking sleeping pills, aging, nasal diseases such as adenoids, and pharyngeal disorders. Because snoring not only hinders the sleep of cohabitants, that is, it brings troubles to others, but also hinders sound sleep, leading to daytime sleepiness, decreased concentration, vitality, memory, and mental restlessness. It is important for sleep, improving energy during the day, and maintaining good health. [0003] In addition, about 10-20% of peop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A23L2/38A23L2/52A23L2/66A23L33/17A23L33/18A61K31/198A61P11/00A61P43/00
CPCA23V2002/00A61K31/198A23K20/142A23L33/175A61P11/00A61P43/00A23V2250/0622A61K45/00
Inventor 柴原进坂井良成
Owner AJINOMOTO CO INC
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