The invention relates to a prostate health-care wine and a preparation method thereof. The prostate health-care wine is prepared from corn wine and contains the effective components of antler, eucommia, wolfberry fruit, Chinese angelica, polygonatum canaliculatum, corydalis tuber, mint, honeysuckle, prepared fleece flower root, emblic leafflower fruit and stevia. The preparation method comprises the following steps of: heating each medicine with 60 degree corn wine at a ratio of 1:20 to 50-70 DEG C, maintaining the temperature for 3-5 hours, sealing and soaking at normal temperature for 10-15days, and filtering the soaked liquid to separately obtain antler wine, eucommia wine, wolfberry fruit wine, Chinese angelica wine, polygonatum canaliculatum wine, corydalis tuber wine, mint wine, honeysuckle wine, prepared fleece flower root wine, emblic leafflower fruit wine and stevia wine; mixing to obtain a prostate health-care raw wine; and blending the prostate health-care raw wine with distilled water to obtain a prostate health-care wine finished product with alcohol content of 35-45 degree. The common drinking amount of the prostate health-care wine is 20-50 mL every day before bedtime; and the prostate health-care wine can adjust integral function, improve nutrient absorption of a human body, resist and control the generation and development of various prostate diseases and hasthe action of promoting sleeping.