Method of replenishing cells damaged by treatment for cancer

A cancer treatment and cell destruction technology, applied in animal cells, extracellular fluid diseases, vertebrate cells, etc., can solve problems such as side effects

Inactive Publication Date: 2006-08-30
REGENETECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although these drugs help reduce some problems and provide some relief, they also have side effects that create a new set of problems for patients

Method used

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Embodiment Construction

[0014] The invention will be more fully illustrated by the preferred embodiments described hereinafter.

[0015] In a preferred embodiment of the invention, the hematopoietic cells are removed from the cancer patient prior to chemotherapy. The blood cells here refer to pluripotent adult stem cells. The blood cells are placed in a bioreactor such as that described in US Patent No. 5,702,941, which is incorporated herein by reference. The bioreactor vessel is rotated at a speed such that the blood cells remain in suspension, thereby maintaining its three-dimensional geometry as well as its cell-cell support and geometric position. While the cells are in the reactor, nutrients are supplied and toxic substances are removed. Cells are expanded to substantially more volume than the starting cells. Chemotherapy is then given to the patient.

[0016] In another embodiment of the invention, peripheral blood (PB) cells are obtained from normal stem cell (SC) donors. Briefly, mononu...

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Abstract

Disclosed herein is a method of replenishing cells damaged by treatment for cancer. The method comprises removing blood cells from a primate mammal, controllably expanding the cells at a rate which produces an expansion factor of at least 700% within 7 days while maintaining their three-dimensional geometry and their cell-to-cell support and cell-to-cell geometry, removing any toxic materials from the blood cells, and reintroducing the cells into the primate mammal within a time period sufficient to prevent the primate mammal from suffering decreased mobility due to loss of hematopoietic or other cells.

Description

Background of the invention [0001] The present invention relates to methods of replenishing cells destroyed by cancer treatment. [0002] One of the most serious side effects of chemotherapy in cancer treatment is the patient's loss of energy due to the loss of red blood cells. In the process of destroying cancer cells, chemotherapy often destroys rapidly dividing cells, such as bone marrow cells. The bone marrow is responsible for the production of red blood cells, white blood cells and platelets. Decreased bone marrow activity is called myelosuppression. Chemotherapy and radiation therapy can reduce red blood cell counts to low levels, which can eventually lead to fatigue, lack of energy, and anemia. Myelosuppression is the dose-limiting toxicity of most effective chemotherapeutic drugs. In recent years, this limitation has been overcome through the use of SC transplantation (SCT). In fact, the implementation of SCT after high-dose chemotherapy can further accelerate th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/14A61P7/00A61K35/28
CPCC12N2501/125C12N2501/22C12N5/0634A61K35/14A61K35/28A61P7/00A61P43/00
Inventor 唐尼·拉德
Owner REGENETECH INC
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