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Medicine composition and preparing method

A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its preparation, can solve the problems of uncertain curative effect, incomplete understanding of mechanism, and the advent of empirical Chinese medicine preparations for depression, etc.

Inactive Publication Date: 2006-10-25
余述南
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to clinical reports, decoctions are mainly used, and traditional prescriptions or self-made prescriptions are added or subtracted according to the syndrome, but the curative effect is not exact, and the mechanism is not completely clear.
[0005] Clinical depression and anxiety are treated according to TCM syndrome differentiation. The syndrome of liver stagnation transforming into fire is the most common in the early and middle stages. The advent of traditional Chinese medicine preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0036] Experimental example 1. the influence of capsule of the present invention on mouse tail suspension

[0037] group

dosage

number of animals

Immobility time (s)

control group

Clomipramine group

Capsules of the present invention

20mg / kg

0.3g / kg

0.6g / kg

1.2g / kg

13

12

12

10

10

103.92±53.78

40.83±43.89**

79.08±50.77

57.80±35.29*

42.40±47.62**

[0038] *P<0.05, **P<0.01 compared with the control group

[0039] The results in Table 1 show that both the high and medium dose groups of the capsules of the present invention can significantly shorten the tail suspension time of mice, and the difference is significant compared with the blank group (P<0.01, P<0.05).

experiment example 2

[0040] Experimental example 2. the influence of capsule of the present invention on mice's forced swimming

[0041] group

dosage

number of animals

Immobility time (s)

control group

Clomipramine group

Capsules of the present invention

20mg / kg

0.3g / kg

0.6g / kg

1.2g / kg

15

13

13

13

11

108.06±41.05

58.84±28.72**

90.46±40.78

73.00±35.80*

68.63±38.24**

[0042] *P<0.05, **P<0.01compared with control compared with control group

[0043] The results in Table 2 show that both the high and middle dose groups of the capsules of the present invention can significantly shorten the immobility time of mice forced to swim, and the difference is significant compared with the blank group (P<0.01, P<0.05).

experiment example 3

[0044] Experimental Example 3. Effects of Capsules of the Present Invention on Reserpine-induced Mouse Body Temperature Drop

[0045] group

Dose (g / kg)

Number of animals (n)

body temperature (°C)

Blank control group

Reserpine group

Anafranil group

Capsules of the present invention

0.0016

0.02

0.3

0.6

1.2

10

10

9

10

9

10

37.86±0.622)

35.70±0.60

36.66±0.712)

36.12±0.55

36.56±1.031)

36.94±0.862)

[0046] *P<0.05, **P<0.01 compared with the control group

[0047] The results in Table 3 show that the high and middle dose groups of the capsules of the present invention can significantly resist the drop in body temperature of mice caused by reserpine, and the difference is significant compared with the blank group (P<0.01, P<0.05).

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PUM

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Abstract

The present invention relates to a Chinese medicine composition for curing depression and anxiety neurosis with obvious therapeutic effect. It is made up by using Chinese medicinal materials of forsythia fruit, curcuma tuber, acorus root, ginseng, polygala root and silk tree flower as main raw material and adding beta-cyclodextrin as auxiliary material through a certain preparation process. It can be made into capsule preparation.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating depression or anxiety and a preparation method thereof, belonging to the field of medicine. Background technique [0002] With the intensification of various emergency factors, depression has become a common disease in modern society, with a high incidence rate, and its incidence rate is rising rapidly. According to incomplete statistics, patients with depression account for 3%-5% of the world's population. [0003] Modern pharmacological studies have shown that the pathogenesis of depression is very complex, and there are many causes, and it is often difficult to achieve satisfactory curative effect with drugs targeting a single link. Most synthetic antidepressants have defects such as narrow antidepressant spectrum, large side effects, high drug price and easy relapse. Therefore, more and more traditiona...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/00A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P25/22A61P25/24
Inventor 高学敏张建军王景霞张德芹
Owner 余述南
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