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Human beta-defensin secretion promoter

A technology of beta defensin and enhancer, applied in the field of beta defensin secretion enhancer, can solve problems such as insufficient identification and ambiguity

Inactive Publication Date: 2006-10-25
OTSUKA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanism of production and secretion of human β-defensins has not yet been fully elucidated.
Methods for promoting the secretion of human β-defensins other than the above-mentioned substances are not yet clear

Method used

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  • Human beta-defensin secretion promoter
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1 chewing gum

[0071] The chewing gums of the following formulations were manufactured according to the usual method.

[0072] Compounding amount (weight%)

[0073] lime powder 5.0

[0074] (Contains citric acid 75% by weight in lime powder)

[0075] Gum base (main component: vinyl acetate) 22.0

[0076] Xylitol 35.0

[0077] Maltitol 27.0

[0078] Appropriate amount of spices

[0079] Total 100% by weight

Embodiment 2

[0080] Example 2 Lemon Pastry

[0081] The lemon pastry of the following recipe was made according to the usual method.

[0082] Compounding amount (weight%)

[0083] Malic acid 7.5

[0084] Sodium bicarbonate 7.5

[0085] Xylitol 40.0

[0086] Maltitol 30.0

[0087] Cornstarch 15.0

[0088] Total 100% by weight

Embodiment 3

[0089] Refreshing agent (liquid) in the mouth of embodiment 3

[0090] The mouth-cooling agent (liquid form) of the following prescription was manufactured according to the usual method.

[0091] Compounding amount (weight%)

[0092] Lactose 0.2

[0093] 1-menthol 1.0

[0094] Ethanol 40.0

[0095] Glycerin 20.0

[0096] Capric Glyceryl Monolaurate 0.5

[0097] Spice 0.1

[0098] Pure water remaining

[0099] Total 100% by weight

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PUM

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Abstract

It is intended to provide a human beta-defensin secretion promoter which is usable in various forms such as external preparations, internal preparations and foods and can promote the secretion of human beta-defensin. An organic acid has an effect of promoting the secretion of human beta-defensin, in particular, human beta-defensin-2. Thus, the organic acid is used as the active ingredient of a human beta-defensin secretion promoter. By adding this human beta-defensin secretion promoter to external preparations, internal preparations or foods, an effect of promoting human beta-defensin secretion can be imparted to these products.

Description

technical field [0001] The invention relates to a β-defensin secretion accelerator capable of promoting β-defensin secretion. Furthermore, the present invention also relates to a method for promoting the secretion of beta defensins. Background technique [0002] It is well known that in plants, insects, amphibians, mammals, etc., there are antibacterial substances (antimicrobial peptides) in their bodies as innate defense mechanisms in the body. This is called innate immunity and acts as a local defense against infection. It is currently known that defensins, one of the antimicrobial peptides in the human body, have antibacterial activity against bacteria, fungi, protozoa, viruses, etc., and participate in various body defense mechanisms in the body. [0003] β-defensins are known as defensins that appear on mucosal epithelium of the skin, lungs, trachea, kidneys, genitals, and the like. Now, six kinds of human beta defensins (human beta defensin-1, human beta defensin-2,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K8/36A61K31/191A61K31/192A61K31/194A61K31/198A61K31/375A61P1/02A61P1/04A61P11/00A61P11/02A61P17/00A61P17/02A61P17/10A61P17/16A61P27/02A61P29/00A61P31/04A61P31/10A61P31/16A61P31/18A61P31/22A61P33/00A61P35/00A61P37/04A61P37/08A61P43/00A61Q11/00
CPCA61K31/19A61K31/191A61K31/192A61K31/194A61K31/198A61K31/375A61P1/02A61P1/04A61P11/00A61P11/02A61P17/00A61P17/02A61P17/10A61P17/16A61P27/02A61P27/16A61P29/00A61P31/04A61P31/10A61P31/12A61P31/16A61P31/18A61P31/22A61P33/00A61P35/00A61P37/02A61P37/04A61P37/08A61P43/00
Inventor 五十岚幸代田中英男高须修筱原茂生田中雅彦矢后美里
Owner OTSUKA PHARM CO LTD
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