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Therapeutic use of factor XI

A factor, patient's technology, applied in the field of pharmaceutical preparations, can solve problems such as difficult and unsuccessful treatment

Inactive Publication Date: 2006-12-20
NOVO NORDISK AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once a subject has developed these serious complications, a cascade of events is initiated, involving numerous cytokines and inflammatory responses, making treatment extremely difficult or often unsuccessful

Method used

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  • Therapeutic use of factor XI
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  • Therapeutic use of factor XI

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0231] Embodiment 1: A method of treating a bleeding episode comprising administering to a patient in need thereof a formulation comprising Factor XI (FXI) or a FXI-related polypeptide in an amount effective for such treatment.

Embodiment approach 2

[0232] Embodiment 2: The method as described in Embodiment 1, wherein said administering results in a reduction in clotting time in said patient.

Embodiment approach 3

[0233] Embodiment 3: The method as described in Embodiment 1 or Embodiment 2, wherein said administering results in promoting hemostasis in said patient.

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Abstract

The present invention provides methods and compositions for treating bleeding episodes. The methods are carried out by administering to a patient in need thereof a preparation comprising a factor XI polypeptide, in an amount effective for such treatment. The methods of the invention result in one or more of: reduced clotting time; enhancement of hemostasis; increase in clot lysis time; increase in clot strength; and / or increase in overall clot quality (OCQ) in said patient.

Description

field of invention [0001] The present invention relates to the use of human factor XI in the prevention and / or treatment of bleeding episodes, methods for purifying factor XI and factor XI polypeptides from biological fluids, and pharmaceutical preparations. Background of the invention [0002] Human factor XI is a serine protease composed of two identical subunits each having a molecular weight of approximately 80 kDa. FXI circulates in plasma as a disulfide-linked homodimer with a molecular weight of -160 KDa. via the Arg 369 with Ile 370 FXI is activated by cleavage of each monomer in between, forming a 50 kDa amino-terminal heavy chain and a 35 kDa carboxy-terminal light chain linked by a disulfide. The protein consists of a 23kb gene located on chromosome 4 (4q35) (consisting of 15 exons and 14 introns, encoding an mRNA consisting of 2,097 nucleotides, which in turn encodes an amino-terminal Signal (leader) peptide and 607 amino acids present in...

Claims

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Application Information

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IPC IPC(8): A61K38/36A61K38/10A61P7/00A61P7/04
Inventor R·勒伊克耶尔D·维乌夫S·厄斯特高S·B·延森J·J·汉森
Owner NOVO NORDISK AS
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