Medicine composition of trifusal and clopidogrel

A technology of clopidogrel and composition, which is applied in the field of pharmaceutical composition containing these two active ingredients, and can solve problems such as allergies and increased risks

Inactive Publication Date: 2007-01-03
陈文展
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the use of aspirin is also limited clinically. For example, many patients are allergic to aspirin; the risk of upper gastrointestinal bleeding i

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of Triflusal and Clopidogrel Compound Soft Capsules

[0025] Take 150g of triflusalox and 50g of clopidogrel, mix them evenly, add 300g of soybean oil, 6g of beeswax, mix them evenly, and make 1000 soft capsules.

Embodiment 2

[0026] Example 2: Preparation of Triflusal and Clopidogrel Compound Soft Capsules

[0027] The same prescription ratio as in Example 1 is: 350 g of triflusal and 50 g of clopidogrel are made into 1000 capsules.

Embodiment 3

[0028] Example 3: Preparation of Triflusal and Clopidogrel Compound Soft Capsules

[0029] The same prescription ratio as in Example 1 is: 100 g of triflusal and 300 g of clopidogrel are made into 1000 capsules.

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PUM

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Abstract

The medicine composition has synergistic active components trifusal and clopidogrel, and its clopidogrel exists in free state or pharmaceutically acceptable salt. The medicine composition is used in treating stable or unstable angina pectoris and other cardiac and cerebral vascular diseases. Pharmaceutical experiments prove the synergistic effect of trifusal and clopidogrel in the medicine composition and the medicine composition has blood platelet inhibiting rate superior to that of aspirin-clopidogrel composition and high safety suitable for long -term taking.

Description

Technical field: [0001] The present invention relates to a novel combination with anti-platelet aggregation activity consisting of triflusalox and clopidogrel, and a pharmaceutical composition containing the two active ingredients. Background technique: [0002] Vascular disease is a systemic disease. The clinical manifestations are different due to the different sites of thrombosis. A vascular event occurs in one vessel, which means that the risk of vascular events in other vessels increases. According to statistics, the death caused by atherosclerotic thrombosis accounts for 28.7% of the total death of the population, mainly due to coronary artery events and cerebral artery events, followed by other peripheral arterial diseases, and two or even three vascular lesions may coexist . The pathological basis of vascular events is atherosclerosis, and the first step in pathophysiology is platelet activation. Therefore, antiplatelet therapy is crucial for the prevention of vascu...

Claims

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Application Information

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IPC IPC(8): A61K31/4365A61K31/216A61K9/20A61K9/48A61K9/16A61P7/02A61P9/10
Inventor 陈文展
Owner 陈文展
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