A kind of pharmaceutical composition of triflusal and aspirin

A technology of aspirin and composition, which is applied in the field of pharmaceutical compositions of triflusal and aspirin and their preparation fields, can solve the problems of low serious bleeding complications and the like

Active Publication Date: 2016-08-24
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that trifluxal and aspirin have no difference in preventing serious cardiovascular events in patients with peripheral arteriosclerotic occlusive disease, but the incidence of serious bleeding complications is significantly lower than that of aspirin group

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of triflusal aspirin tablet

[0017] Take 300g of trifluxalil and 81g of aspirin, mix them evenly, add 150g of microcrystalline cellulose, 10g of coach polyvinylpyrrolidone, pulverize, soften with ethanol, granulate after passing through a 60-mesh sieve, dry at 50°C, pass through a 60-mesh sieve for granulation, add 10g of sodium carboxymethyl starch, 2g of aspartame, and 30g of magnesium stearate were evenly mixed, and pressed into 1000 tablets.

Embodiment 2

[0018] Embodiment 2: the preparation of triflusal aspirin capsule

[0019] Take 150g of triflusalil and 100g of aspirin, mix them evenly, add an appropriate amount of dextrin, granulate, and make 1000 capsules.

Embodiment 3

[0020] Example 3: Determination of the influence of triflusal and aspirin compound preparation on thrombosis in rats by thrombus method

[0021] Experimental drugs: triflusalox aspirin tablets (300mg: 81mg and 150mg: 100mg); normal saline; aspirin; triflusalox; compound pharmaceutical composition of aspirin and clopidogrel.

[0022] Experimental animals: 60 SD rats with a body weight of 300-400g, male and female, were randomly divided into ① blank control group (normal saline); ② aspirin-clopidogrel compound pharmaceutical composition; 81 mg); ④ Triflusalox aspirin tablets (150mg: 100mg); ⑤ Triflusalox group; ⑥ Aspirin group; 10 animals in each group.

[0023] Experimental method: Rats were administered orally by gavage, with the same volume (6ml / kg) administered to all animals, administered once a day for 5 days in total. On the 5th day of administration, 1 hour after the last administration, the animals were weighed and anesthetized by intravenous infusion of 3% pentobarbit...

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PUM

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Abstract

The invention provides a pharmaceutical composition of triflusal and aspirin, and a preparation method. In the pharmaceutical composition, the triflusal exists in a free state or a form of a pharmaceutical acceptable salt. The pharmaceutical composition can be applied to treatment of a cardiovascular system disease and a cerebral vessel system disease. The pharmacological experiment proves that combined utilization of the triflusal and the aspirin is significantly better than a single ingredient control group and a placebo group in effect, the platelet inhibition ratio of the compound pharmaceutical composition of the triflusal and the aspirin is significantly better than that of the compound pharmaceutical composition of the triflusal and the aspirin, and the pharmaceutical composition is also applicable to long-term use of a sufferer by increase of the safety.

Description

technical field [0001] The invention relates to medicines in the medical field, in particular to a pharmaceutical composition of triflusal and aspirin and a preparation method thereof. Background technique [0002] History of vascular disease is a systemic disease with different clinical manifestations due to the different sites of thrombosis, and the occurrence of vascular events in one vessel means that the risk of vascular events in other vessels increases. According to statistics, the death caused by atherosclerotic thrombosis accounts for 28.7% of the total death of the population, mainly due to coronary artery events and cerebral artery events, followed by other peripheral arterial diseases, and two or even three vascular lesions may coexist . The pathological basis of vascular events is atherosclerosis, and the first step in pathophysiology is platelet activation. Therefore, antiplatelet therapy is crucial for the prevention of vascular events. The European Society ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/616A61P9/00A61P7/02
Inventor 严洁李轩
Owner TIANJIN HANKANG PHARMA BIOTECH
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