Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain

A cytokine, selective technology for the treatment, prevention, improvement and control of pain

Inactive Publication Date: 2007-01-17
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few patients experience complete healing of their pain

Method used

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  • Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
  • Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
  • Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain

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Embodiment Construction

[0042] The present invention is partly based on the idea that the compounds disclosed in the present invention can act alone or in combination with other drugs to effectively treat, prevent, improve and / or control various types and severity of pain. Without being bound by theory, the compounds of the invention may, but need not be, act as analgesics. Specifically, because certain compounds can surprisingly affect the production of cytokines (e.g., TNF-α, IL-1β, IL12, and IL-4), it is thought that they may be effective by reducing the baseline Or restore the normal pain domain and have the function of "anti-hyperalgesia" and / or "neuromodulator". Thus, the compounds of the present invention may exert different effects from analgesics, which generally only reduce stimulus-induced responses, whereas the compounds of the present invention may act by inhibiting pain-related distress or directly reducing the reactivity of nociceptors. Alter the patient's ability to tolerate this res...

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PUM

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Abstract

Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and / or surgery, psychological or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Description

1. Field of invention [0001] The present invention relates to methods for treating, preventing, ameliorating and controlling pain, which method comprises administering selective cytokine inhibitory drugs alone or in combination with known therapies. Specifically, the invention includes the use of selective cytokine inhibitory drugs in combination with other standard treatments for nerve blockade and / or pain symptoms. 2. Background of the invention [0002] Pain is the first symptom of many different diseases and is defined as an unpleasant sensory and emotional experience associated with or described in terms of actual or potential tissue damage. Merskey H, Bogduk N, eds., Classification of Chronic Pain, International Association for the Study of Pain (IASP) Classification Special Section, IASP Press: Seattle, 209-214, 1994. Because the perception of pain is highly subjective, it is one of the most difficult conditions to diagnose and treat effectively. Pain severely impai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N43/42A01N43/38A61K31/52A61K31/44A61K31/47A61K31/40A61KA61K31/415A61K31/445A61K31/454
CPCA61K31/60A61K31/4035A61K45/06A61P17/02A61P19/02A61P19/04A61P19/08A61P21/00A61P25/00A61P25/02A61P25/04A61P29/00A61P37/02A61P43/00A61P3/10A61K2300/00A61K31/445A61K31/519A61K31/47
Inventor 杰罗米·B·杰奥迪斯赫伯特·费莱克唐纳德·C·曼宁
Owner CELGENE CORP
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