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Method for treating leishmaniasis using methyl-beta-cyclodextrin

a technology of beta cyclodextrin and leishmaniasis, which is applied in the directions of biocide, spray delivery, aerosol delivery, etc., to achieve the effect of safe and efficient composition

Inactive Publication Date: 2004-06-24
COUNCIL OF SCI & IND RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] Still another object of the present invention is to develop a safe and efficient composition for the management of leishmaniasis.
[0010] Still another object of the present invention is to develop a safe and efficient composition comprising methyl-beta-cyclodextrin for the management of leishmaniasis.

Problems solved by technology

However, the large number of different receptors responsible for the attachment and internalization of the parasite to macrophages have contributed to the fact that no single panacea has yet been developed for the treatment of leishmaniasis.

Method used

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  • Method for treating leishmaniasis using methyl-beta-cyclodextrin
  • Method for treating leishmaniasis using methyl-beta-cyclodextrin
  • Method for treating leishmaniasis using methyl-beta-cyclodextrin

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Embodiment Construction

[0012] Accordingly, the present invention relates to a composition useful for the treatment of leishmaniasis said composition comprising pharmaceutically effective amount of methyl-beta-cyclodextrin, optionally along with other anti-leishmanial agent(s) and / or pharmaceutically acceptable additives, and a method thereof, wherein the said method reduces the cholesterol levels of the plasma membrane of the infected host cells by about 50%.

[0013] The main embodiment of the present invention is a method of treating leishmaniasis said method consisting of step of administering a composition comprising pharmaceutically effective amount of methyl-beta-cyclodextrin optionally along with other anti-leishmanial agent(s) and / or pharmaceutically acceptable additives, to a subject in need thereof.

[0014] In another main embodiment of the present invention, wherein the said method reduces the cholesterol levels of the plasma membrane of the infected host cells by about 50%.

[0015] In still another m...

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Abstract

The present invention relates to a composition useful for the treatment of leishmaniasis said composition comprising pharmaceutically effective amount of methyl-beta-cyclodextrin, optionally along with other anti-leishmanial agent(s) and / or pharmaceutically acceptable additives, and a method thereof, wherein the said method reduces the cholesterol levels of the plasma membrane of the infected host cells by about 50%.

Description

FIELD OF THE PRESENT INVENTION[0001] The present invention relates to a composition useful for the treatment of leishmaniasis said composition comprising pharmaceutically effective amount of methyl-beta-cyclodextrin, optionally along with other anti-leishmanial agent(s) and / or pharmaceutically acceptable additives, and a method thereof, wherein the said method reduces the cholesterol levels of the plasma membrane of the infected host cells by about 50%.BACKGROUND AND PRIOR ART OF THE PRESENT INVENTION[0002] Leishmania are protozoan parasites that are responsible for substantial public health problems, especially in tropical and subtropical regions. In a recent survey, 88 countries have been declared as leishmaniasis-endemic.sup.7. The current increase in leishmaniasis throughout the world to epidemic proportion coupled with increasing incidence of the disease in developed countries, and emergence of visceral leishmaniasis as an important opportunistic infection among people with hum...

Claims

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Application Information

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IPC IPC(8): A61K31/724
CPCA61K9/0024A61K9/0073A61K9/20A61K31/724A61K45/06A61K2300/00Y02A50/30
Inventor CHATTOPADHYAY, AMITABHAMADHUBALA, RENTALA
Owner COUNCIL OF SCI & IND RES
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