Anti-inflammatory compositions and methods of use
Patent Information
- Authority / Receiving Office
- US · United States
- Patent Type
- Applications(United States)
- Current Assignee / Owner
- MCMASTER BRIAN
- Publication Date
- 2007-03-29
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
[0001] Defense Advanced Research Projects Agency (DARPA) Grant No. N65236-99-1-5420.BACKGROUND OF THE INVENTION
[0002] The present invention is directed to pharmaceutical compositions containing active compounds and their pharmaceutically acceptable salts, which inhibit the binding of various chemokines, such as MIP-1α and RANTES, to the CCR1 receptor It also is directed to methods of treating inflammatory and immunoregulatory disorders and diseases using these pharmaceutical compositions.
[0003] Human health depends on the body's ability to detect and destroy foreign pathogens that might otherwise usurp valuable resources from the individual and / or induce illness. The immune system, which comprises leukocytes (white blood cells (WBCs): T and B lymphocytes, monocytes, eosinophils, basophils, and neutrophils), lymphoid tissues and lymphoid vessels, is the body's system of defense. To combat infection, B and T lymphocytes circulate throughou...