Methods using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of mantle cell lymphomas

Inactive Publication Date: 2008-02-14
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011] This invention encompasses methods of treating, preventing or managing certain types of lymphomas, including primary and metastatic cancer, as well as cancers that are relapsed, refractory or resistant to conventional chemotherapy. In particular, methods of this invention encompass methods of treating, preventing or managing various forms of lymphomas

Problems solved by technology

MCL has poor clinical outcome and is an incurable lymphoma with limited therapeutic options for patients with relapsed or refractory disease.

Method used

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  • Methods using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of mantle cell lymphomas

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Embodiment Construction

[0016] A first embodiment of the invention encompasses methods of treating, managing, or preventing certain types of lymphomas which comprises administering to a patient in need of such treatment, management or prevention a therapeutically or prophylactically effective amount of an immunomodulatory compound of the invention, or a pharmaceutically acceptable salt, solvate (e.g., hydrate), stereoisomer, clathrate, or prodrug thereof. In particular, methods of this invention encompass methods of treating, preventing or managing various forms of lymphomas, including but not limited to, mantle cell lymphoma, MCL, lymphocytic lymphoma of intermediate differentiation, intermediate lymphocytic lymphoma, ILL, diffuse poorly differentiated lymphocytic lymphoma, PDL, centrocytic lymphoma, diffuse small-cleaved cell lymphoma, DSCCL, follicular lymphoma, and any type of the mantle cell lymphomas that can be seen under the microscope (nodular, diffuse, blastic and mentle zone lymphoma). In one em...

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Abstract

Methods of treating, preventing or managing mantle cell lymphomas are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide. The invention further relates to methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods of the invention are also disclosed.

Description

[0001] This application claims the benefit of U.S. provisional application 60 / 835,752, filed Aug. 3, 2006, the entirety of which is incorporated by reference herein.1. FIELD OF THE INVENTION [0002] This invention relates to methods of treating, preventing or managing certain types of lymphomas with an immunomodulatory compound having the chemical name of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione, which is also known as or lenalidomide, Revlimid® or Revimid®. In particular, this invention encompasses methods of treating, preventing or managing non-Hodgkin's lymphomas, including but not limited to, mantle cell lymphoma (MCL), lymphocytic lymphoma of intermediate differentiation, intermediate lymphocytic lymphoma, ILL, diffuse poorly differentiated lymphocytic lymphoma, PDL, centrocytic lymphoma, diffuse small-cleaved cell lymphoma, DSCCL, and mentle zone lymphoma, using the compound alone as a therapeutic. [0003] The invention also encompasses the use of specifi...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K39/395A61P35/00
CPCA61K31/454A61K39/39558A61K45/06A61K39/3955A61K2300/00A61K31/573A61P35/00A61P35/02A61P37/02A61K39/395A61K9/0019A61K9/0053
InventorZELDIS, JEROME B.
OwnerCELGENE CORP