Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same

a technology of oncolytic agent and newcastle disease virus, which is applied in the field of recombinant strains of avian paramyxoviruses, can solve the problems of incomplete understanding of the exact cellular pathways involved in virus-induced apoptosis and the mechanistic basis of oncolysis

Inactive Publication Date: 2009-07-09
UNIV OF MARYLAND OFFICE OF TECH COMMLIZATION
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Problems solved by technology

However, the exact cellular pathways involved in virus-induced apoptosis and the mechanistic basis of oncolysis are still incompletely understood.
It carries a serious respiratory and neurological disease in all species of birds, but infections in humans are rare, and any such infections typically result in no more than mild conjunctivitis.

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  • Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same
  • Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same
  • Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same

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[0069]The present invention relates to recombinant oncolytic avian paramyxoviruses (APMV), such as Newcastle disease virus (NDV), compositions comprising them, and methods of using them to treat cancer and / or tumors in patient suffering therefrom. The present invention also provides recombinant oncolytic viruses, such as NDV, which incorporate additional therapeutic transgenes into their genomes. Such genetically-engineered oncolytic viruses may be used in accordance with methods for delivering the oncolytic viruses to specific sites and / or specific tumors within the body of a patient. The present invention further relates to methods of identifying recombinant viruses that are useful as oncolytic agents. Preferred embodiments of the present invention and their features and advantages may be understood by referring to FIGS. 1 through 38.

[0070]Newcastle disease virus (NDV), an avian paramyxovirus (APMV), is tumor-selective and intrinsically oncolytic. One aspect of the present inventi...

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Abstract

Recombinant strains of avian paramyxovirus (APMV), such as Newcastle disease virus (NDV), are provided. Also provided are compositions comprising them, and methods of using them to lyse tumor cells and to treat cancer. In certain aspects, genetically-engineered viral strains that incorporate therapeutic transgenes are also provided. The recombinant viruses may be used in accordance with methods of providing enhanced oncolytic efficacy and delivering an oncolytic virus to tumors present in a patient. Also provided are methods for identifying a recombinant virus as an oncolytically-effective agent.

Description

RELATED APPLICATION DATA[0001]This application claims priority from U.S. Provisional Application No. 60 / 803,924, which was filed on Jun. 5, 2006. The contents of this application are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates generally to recombinant strains of avian paramyxoviruses (APMV) and their use as oncolytic agents. In particular, the present invention is directed towards recombinant Newcastle disease virus (NDV) that exhibits enhanced oncolytic efficacy, and particularly to recombinant NDV that incorporates one or more additional therapeutic transgenes. The present invention also relates to methods of treating cancer by administering recombinantly-produced NDV to a patient. The present invention further relates to methods of providing targeted delivery of a recombinant NDV to specific sites in a patient, as well as methods of identifying recombinant NDV useful as oncolytic ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/76C12N15/00C12N5/06C12Q1/70A61K35/13
CPCA61K35/13C12N7/00C12N15/86C12N2760/18143C12N2760/18121
Inventor SUBBIAH, ELANKUMARANSAMAL, SIBA K.
Owner UNIV OF MARYLAND OFFICE OF TECH COMMLIZATION
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