Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Modified Oncolytic Viruses

a technology of oncolytic viruses and modified oncolytic peptides, which is applied in the direction of virus peptides, biocide, plant growth regulators, etc., can solve the problems of insufficient binding of the prototype strain of cva21 to the surface expressed daf, and insufficient to initiate a productive infection

Inactive Publication Date: 2012-12-27
VIRALYTICS
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, viral binding to DAF alone is insufficient to permit enteroviral infections and interactions with DAF do not induce 135S altered (A) particles, which are considered to be a prerequisite for cell entry.
Binding of the prototype strain of CVA21 to surface expressed DAF is, however, not sufficient to initiate a productive infection or formation of A-particles, and interaction with ICAM-1 is required for cell entry.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Modified Oncolytic Viruses
  • Modified Oncolytic Viruses
  • Modified Oncolytic Viruses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0063]Although it is known that some naturally occurring Picornavirus and other viruses such as reoviruses are suitable for use in treatment of limited types of cancers, there is still a need to develop improved treatments. In order to expand the possible range of cancer treatment and provide even more efficacious treatments, the present inventors have obtained a new oncolytic Picornavirus with improved oncolytic properties by modification and bioselection.

[0064]As described herein, the present inventors have discovered that wild-type Picornavirus can be bioselected to lytically infect cells expressing DAF and not ICAM-1, such cells usually are resistant to wild-type Picornavirus infection. “Resistance” of cells to Picornavirus infection indicates that infection of the cells with the virus did not result in significant viral production or yield. Cells that are “susceptible” are those that demonstrate induction of cytopathic effects, viral protein synthesis, and / or virus production.

[...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides an isolated selected Picornavirus capable of lytically infecting or inducing apoptosis in a cell substantially in the absence of intercellular adhesion molecule-1 (ICAM-1), and methods for treating subjects.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation application of U.S. application Ser. No. 10 / 592,395 filed Jul. 3, 2007, now pending; which is a 35 USC §371 National Stage application of International Application No. PCT / US2005 / 000048 filed Jan. 17, 2005; which claims the benefit under 35 USC §119(e) to U.S. Application Ser. No. 60 / 552,095 filed Mar. 11, 2004, now expired. The disclosure of each of the prior applications is considered part of and is incorporated by reference in the disclosure of this application.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to modified oncolytic Picornavirus and methods for treating subjects.[0004]2. Background Information[0005]The attachment of viruses to cell surface molecules is the Initial step of virus replication and specific cellular virus receptors are, therefore, major determinants for virus tissue tropism. Decay-accelerating factor (DAF / CD55), a 70 kDa glycosyl ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/76A61P35/02A61P35/00A61K48/00C07K14/085C12N9/50C12N15/41
CPCA61K48/00C07K14/005A61K35/768C12N2770/32332C12N2770/32322A61P35/00A61P35/02A61P43/00Y02A50/30
Inventor JOHANSSON, EVA SUSANNESHAFREN, DARREN RAYMOND
Owner VIRALYTICS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com