Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drug discovery methods and platforms

a technology of drug discovery and platform, applied in the field of drug discovery, can solve the problems of difficult finding new drugs, scientists still struggle to identify therapeutic compounds with the right mix of medicinal and cancer-targeting properties,

Inactive Publication Date: 2014-06-26
FRED HUTCHINSON CANCER RES CENT
View PDF2 Cites 26 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text explains how different publications, patents, and patent applications are incorporated by reference. This means that each individual document is individually detailed and mentioned in the text as being incorporated by reference. The technical effect of this is that it provides a way for R&D personnel to easily access and use different sources of information when developing new products or services.

Problems solved by technology

Unfortunately, finding new drugs has continued to be difficult.
But even after decades of research, scientists still struggle to identify therapeutic compounds with the right mix of medicinal and cancer-targeting properties.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug discovery methods and platforms
  • Drug discovery methods and platforms
  • Drug discovery methods and platforms

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0156]This example describes a method for expressing peptide constructs in culture, allowing for the rapid generation of known and novel knottins and greatly facilitating their development, particularly as drugs.

[0157]As shown in FIG. 7, the various knottins can be expressed, e.g., in a lentivirus expression-based method that can include packaging, transfer, and then expression followed by isolation and / or purification of the expressed knottin peptides. Several coding constructs can be used. In this example, the encoding of the knottin peptides included a polynucleotide construct including IgK SP-sFLAG-HIS-Siderocalin-TEV-Knottin. Specific sequences of some example constructs are disclosed in Appendix I below. FIG. 8 shows gel data of a number of example knottins that were made according to the method described in FIG. 7. As shown, chlorotoxin (CTX), chymotrypsin inhibitor (CTI), epiregulin (EPI), hefutoxin (HTX), bubble protein (BUB), potato carboxypeptidase inhibitor (PCI) were pr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. Methods of making and using peptide libraries are also provided. D-amino acid chlorotoxins and D-amino acid chlorotoxin variants are also provided.

Description

CROSS-REFERENCE[0001]This application claims the benefit of U.S. Provisional Application No. 61 / 735,516, filed Dec. 10, 2012, and U.S. Provisional Application No. 61 / 794,685, filed Mar. 15, 2013, the contents of each of which is hereby incorporated by reference in their entirety.STATEMENT AS TO FEDERALLY SPONSORED RESEARCH[0002]This invention was made with the support of the United States government under Contract number R01CA135491 by the National Institutes of Health.BACKGROUND OF THE INVENTION[0003]Efforts towards drug discovery continue to use vast technical and financial resources to identify and develop new and useful drugs. Unfortunately, finding new drugs has continued to be difficult. For example, development of less damaging, more precisely targeted cancer therapies is essential in order to relieve patients' suffering and improve treatment success. But even after decades of research, scientists still struggle to identify therapeutic compounds with the right mix of medicina...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/53
CPCG01N33/5308C07K14/47C07K2319/00A61K38/1767C12N9/0083C12Y114/99003A61P25/00A61P29/00A61P3/00A61P31/00A61P35/00A61P37/02A61P43/00A61P9/00G01N33/5008C07K14/43522A61K49/00A61K45/06G01N2500/00G01N2500/10G01N2500/20C07K16/00
Inventor OLSON, JAMESMEHLIN, CHRISTOPHERSTROUD, MARKSIMON, JULIANCORRENTI, COLINPADDISON, PATRICKSTRONG, ROLANDMAY, DAMON
Owner FRED HUTCHINSON CANCER RES CENT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com