Triple antibiotic cationic ointment

Abstract

The present disclosure generally relates to petrolatum-based compositions for suspension of active ingredients and methods for forming stable suspensions of active ingredients in petrolatum, and more specifically to compositions of triple antibiotic cationic ointments. In particular, the present disclosure relates to a method for suspension of antibiotics and biocides in petrolatum at room temperature and a petrolatum-based composition having a stable suspension of active ingredients including antibiotics and biocides.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application claims priority to U.S. Provisional Application Ser. No. 62 / 125,926, filed Feb. 5, 2015 and International Application No. PCT / US2016 / 016629, filed Feb. 4, 2016, the entire contents of which are hereby incorporated by reference.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002](Not applicable)BACKGROUND OF THE INVENTIONField of the Invention[0003]The present disclosure generally relates to petrolatum-based compositions for suspension of active ingredients and methods for forming stable suspensions of active ingredients in petrolatum, and more specifically to compositions of triple antibiotic cationic ointments. In particular, the present disclosure relates to a method for suspension of antibiotics and biocides in petrolatum at room temperature and a petrolatum-based composition having a stable suspension of active ingredients including antibiotics and biocides.Description of the Related Art[0004]T...

AI Technical Summary

Problems solved by technology

A problem that is often encountered is the separation of the oil and aqueous phases over time, either by coalescing of the dispersed phase, or in some cases, by the combination of dispersed phase portions in a process of flocculation (formation of solid materials within the dispersion / suspension / emulsion that results in separation of the phases, with one in solid or semi-solid form.

Petrolatum is known to have advantageous protective properties when applied to the skin, however, its hydrophobic nature presents challenges with formulating active ingredients.

Petrolatum was also believed to be incapable of delivering active ingredients because the active ingredients would be trapped within the petrolatum and therefore would be unable to reach the desired delivery site.

Combination antibiotic therapy is frequently used to treat severe Gram-negative infections but is controversial and debatable.

However, excessive use of combinations should be avoided because it might be associated with increased risk for toxicity, superinfections, selection of resistant strains, and higher costs.

Antibiotics increase selective pressure in bacterial populations, causing vulnerable bacteria to die; this increases the percentage of resistant bacteria, which continue growing.

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